139425-24-4

Basic information

• Product Name: Benzenemethanol, 3-[2-(7-chloro-2-quinolinyl)ethenyl]-a-methyl-, (E)-
• CAS NO: 139425-24-4
• Molecular Formula: C19H16ClNO
• Molecular Weight: 309.795
• Mol File: 139425-24-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 3-[2-(7-chloro-2-quinolinyl)ethenyl]-a-methyl-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 3-[2-(7-chloro-2-quinolinyl)ethenyl]-a-methyl-, (E)-(139425-24-4)
• EPA Substance Registry System: Benzenemethanol, 3-[2-(7-chloro-2-quinolinyl)ethenyl]-a-methyl-, (E)-(139425-24-4)

Safety Data

• Hazardous Substances Data: 139425-24-4(Hazardous Substances Data)

Usage

Common Use

Antimalarial medication

Chemical Class

Quinoline derivatives

Molecular Structure

Benzene ring
Quinoline ring
Hydroxyl group

Mechanism of Action

Inhibits growth and reproduction of malaria parasite

Stereochemistry

(E)-configuration, indicating trans configuration of the 2-quinolinyl ethenyl side chain

Importance

Effective treatment and prevention of malaria

Potential

Further research and development in antimalarial medications

Upstream product

• 676-58-4 methylmagnesium chloride 
• 120578-03-2 (E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde 

Downstream Products

• 1429879-27-5 (-)-7-chloro-2-[(E)-2-[3-[(2S)-oxiran-2-yl]phenyl]vinyl]quinoline 
• 1429879-26-4 2-Bromo-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-ethanone 
• 878007-03-5 1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)ethanone 

Relevant articles and documents

CYSTEINYL LEUKOTRIENE ANTAGONISTS

The present invention relates to novel cysteinyl leukotriene (specifically LTD4) antagonists, mainly to quinolin, quinoxaline or benz[c]thiazole derivatives represented by the general formula (I), or the pharmaceutically acceptable salt thereof, process of preparation thereof, and to the use of the compounds in the preparation of pharmaceutical compositions for the therapeutic treatment of disorders related to cysteinyl leukotriene, in mammals, more specially in humans.

PREPARATION OF MONTELUKAST AND ITS SALTS

There is provided a process for the preparation of montelukast of the Formula (I).

AZABENZIMIDAZOLES IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES

A series of imidazo[4,5-c]pyridines which inhibit platelet activating factor (PAF) and also block leukotriene D4 receptors are useful in treating asthma, arthritis, psoriasis, gastrointestinal distress, myocardial infarction, stroke and shock.