139484-10-9Relevant articles and documents
InCl3·4H2O-promoted green preparation of xanthenedione derivatives in ionic liquids
Fan, Xuesen,Hu, Xueyuan,Zhang, Xinying,Wang, Jianji
, p. 16 - 20 (2005)
A green procedure for the synthesis of xanthenedione derivatives (3) through InCl3·4H2O-promoted condensation of aldehydes (1) and 5,5-dimethyl-1,3-cyclohexanedione (2) in ionic liquids is described in this paper. This novel method h
An Efficient One-Pot Two-Step Three-Component Process for the Synthesis of Trifluoromethylated Hydrochromenes
Yan, Xufeng,Yang, Yeqing,Han, Jing,Jiang, Guimei,Chen, Jie,Deng, Hongmei,Shao, Min,Zhang, Hui,Cao, Weiguo
, p. 2863 - 2872 (2016)
A one-pot two-step three-component process for the synthesis of trifluoromethylated 2-hydroxy-5-oxo-3,4,5,6,7,8-hexahydro-2H-chromenes has been developed. The three-component reaction of dimedone, substituted benzaldehydes, and methyl 4,4,4-trifluorobut-2-ynoate gave the desired products in moderate to good yields. Excellent regioselectivity and diastereoselectivity were observed. Furthermore, refluxing the product chromenes with p-toluenesulfonic acid in toluene gave the corresponding dehydrated products - trifluoromethylated 5-oxo-5,6,7,8-tetrahydro-4H-chromenes.
Simple and efficient synthesis of 2,2′-arylmethylenebis(3-hydroxy-5,5-dimethyl-2-cyclohexene-1-one) derivatives
Magyar, ágnes,Hell, Zoltán
, p. 2021 - 2023 (2019)
Abstract: A simple and efficient method for the synthesis of 2,2′-arylmethylenebis(3-hydroxy-5,5-dimethyl-2-cyclohexene-1-one) derivatives using 4 ? molecular sieves as catalyst is described. This approach offers several advantages such as high yields, mi
Chemoselective synthesis of xanthenes and tetraketones in a choline chloride-based deep eutectic solvent
Azizi, Najmedin,Dezfooli, Sahar,Hashemi, Mohammad Mahmoudi
, p. 997 - 1001 (2013)
A chemoselective synthesis of tetraketone and xanthene derivatives, by means of tandem Knoevenagel condensation and Michael addition in choline chloride-based deep eutectic solvents (DESs), is presented. The reaction of readily available aldehydes and act
Biotransformation of Active Methylene Compounds by Saccharomyces cerevisiae
Ghasemi, Sabrieh,Habibi, Zohreh,Notash, Behrouz
, p. 856 - 860 (2015)
The biotransformation of several activated CH-acid compounds was examined using Saccharomyces cerevisiae as a biocatalyst. Alkylation-hydroxylation of 1,3-dicarbonyl compounds at the α-position was achieved. Investigation of the reaction of these compound
Preparation and study of the catalytic application in the synthesis of xanthenedione pharmaceuticals of a hybrid nano-system based on copper, zinc and iron nanoparticles
Esmaeili, Mir Saeed,Varzi, Zahra,Taheri-Ledari, Reza,Maleki, Ali
, p. 973 - 996 (2020/11/06)
A novel efficiently mixed transition metal oxides catalytic system with high catalytic activity and heterogeneity constructed of copper and zinc oxide nanoparticles is presented. For preparation of this hybrid catalytic system, carrageenan as a natural polymeric matrix has been chosen to add biocompatibility to the heterogeneous catalyst. Then, the carrageenan textures have been magnetized through the composition with iron oxide nanoparticles. Copper and zinc metallic sites are employed as the main catalytic sites for catalyzing the synthesis of xanthenedione pharmaceutical derivatives from aldehyde and dimedone. Due to the magnetic behavior of the catalyst, the purification process is carried out with high convenience. Herein, a plausible mechanism for the catalytic process is suggested and reusability of the presented catalyst is also investigated. In this report, it has been well-proven that high reaction yields are obtained for xanthenedione derivatives under mild conditions, through applying the presented hybrid catalytic system.
Evaluation of antiviral activity of cyclic ketones against mayaro virus
Dias, Roberto S.,Fernandes, Luciana S.,Lucindo, Marcel S. da S.,Silva, Cynthia C.,Teixeira, Róbson R.,da Silva, ítalo E. P.,da Silva, Milene L.,de Paula, Sérgio O.
, (2021/11/01)
Mayaro virus (MAYV) is a neglected arthropod-borne virus found in the Americas. MAYV infection results in Mayaro fever, a non-lethal debilitating disease characterized by a strong inflammatory response affecting the joints and muscles. MAYV was once consi