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1395084-66-8

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1395084-66-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1395084-66-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,5,0,8 and 4 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1395084-66:
(9*1)+(8*3)+(7*9)+(6*5)+(5*0)+(4*8)+(3*4)+(2*6)+(1*6)=188
188 % 10 = 8
So 1395084-66-8 is a valid CAS Registry Number.

1395084-66-8Relevant articles and documents

A new class of selective and potent 7-dehydrocholesterol reductase inhibitors

Horling, Aline,Müller, Christoph,Barthel, Richard,Bracher, Franz,Imming, Peter

supporting information, p. 7614 - 7622 (2012/11/07)

We prepared a number of N-phenethyltetrahydroisoquinolines structurally related to protoberberines. They were tested for activity against bacteria, fungi, and human leukemia HL-60 cells and also for inhibition of biosynthesis: ergosterol in yeasts and cholesterol in human cells. In the latter assay panel, several of the compounds were distinguished by a strong and selective inhibition of 7-dehydrocholesterol reductase (7-DHCR, EC 1.3.1.21), an enzyme responsible for the conversion of 7-dehydrocholesterol to cholesterol in the last step of cholesterol biosynthesis. In a whole-cell assay, the most active compound 5f showed a much stronger inhibition of overall cholesterol biosynthesis (IC 50 2.3 nM) than BM 15.766 (IC50 500 nM), presently the most selective known inhibitor of 7-DHCR. Since a defect of 7-dehydrocholesterol reductase is associated with Smith-Lemli-Opitz syndrome (SLOS), the potent and selective inhibitors reported here will enable more detailed investigation of the pathogenesis of SLOS.

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