139528-47-5

Basic information

• Product Name: (1R,2S)-α-<1-(dimethylamino)ethyl>-N-phthalimidobenzylamine
• Synonyms: (1R,2S)-α-<1-(dimethylamino)ethyl>-N-phthalimidobenzylamine
• CAS NO: 139528-47-5
• Molecular Weight: 308.38
• Mol File: 139528-47-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1R,2S)-α-<1-(dimethylamino)ethyl>-N-phthalimidobenzylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S)-α-<1-(dimethylamino)ethyl>-N-phthalimidobenzylamine(139528-47-5)
• EPA Substance Registry System: (1R,2S)-α-<1-(dimethylamino)ethyl>-N-phthalimidobenzylamine(139528-47-5)

Safety Data

• Hazardous Substances Data: 139528-47-5(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 552-79-4 (-)-N-methylephedrine 
• 136918-14-4 phthalimide 
• 158837-60-6 O-<(1R,2S)-N-Methylephedrine>-N,N'-diisopropylisourea 

Downstream Products

• 919113-06-7 (1R,2S)-N',N'-dimethyl-1-phenylpropane-1,2-diamine 

Relevant articles and documents

Structural optimization of thiourea-based bifunctional organocatalysts for the highly enantioselective dynamic kinetic resolution of azlactones

This article describes the synthesis of a library of structurally diverse bifunctional organocatalysts bearing both a quasi-Lewis acidic (thio)urea moiety and a Bronsted basic tertiary amine group. Sequential modification of the modular catalyst structure and subsequent screening of the compounds in the alcoholytic dynamic kinetic resolution (DKR) of azlactones revealed valuable structure-activity relationships. In particular, a "hit-structure" was identified which provides e.g. N-benzoyl-tert-leucine allyl ester in an excellent enantiomeric excess of 95%. The Royal Society of Chemistry 2006.

Stereo- and regioselective synthesis of chiral diamines and triamines from pseudoephedrine and ephedrine

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