1397692-21-5Relevant articles and documents
Asymmetric construction of spirocyclohexanonerhodanines catalyzed by simple diamine derived from chiral tert-leucine
Wu, Wenbin,Huang, Huicai,Yuan, Xiaoqian,Zhu, Kailong,Ye, Jinxing
supporting information; experimental part, p. 9180 - 9182 (2012/09/22)
A diamine-catalyzed asymmetric tandem reaction between α,β- unsaturated ketones and rhodanine derivatives has been developed to synthesize various spirocyclic compounds with high stereoselectivities (up to 99% ee and >20:1 dr). The products obtained contain two pharmaceutically relevant features: the biologically active rhodanine moiety embedded in a spirocyclic unit.