1397922-61-0 Usage
General Description
Pyrotinib maleate is a novel kinase inhibitor that is used in the treatment of HER2-positive advanced or metastatic breast cancer. It specifically targets the epidermal growth factor receptor (EGFR), HER2, and HER4, and has been shown to inhibit tumor cell growth and proliferation. Pyrotinib maleate is a small molecule that works by blocking the tyrosine kinase activity of the HER family of receptors, which are overexpressed in certain types of cancer cells. Clinical studies have demonstrated its efficacy in improving progression-free survival and overall survival in patients with advanced HER2-positive breast cancer, making it a promising option for targeted therapy in this patient population.
Check Digit Verification of cas no
The CAS Registry Mumber 1397922-61-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,7,9,2 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1397922-61:
(9*1)+(8*3)+(7*9)+(6*7)+(5*9)+(4*2)+(3*2)+(2*6)+(1*1)=210
210 % 10 = 0
So 1397922-61-0 is a valid CAS Registry Number.
1397922-61-0Relevant articles and documents
CRYSTALLINE FORM I OF TYROSINE KINASE INHIBITOR DIMALEATE AND PREPARATION METHODS THEREOF
-
Paragraph 0023, (2015/05/26)
Provided are crystalline Form I of (R,E)-N-(4-(3-chloro-4-(pyridin-2-yl -methoxy)-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl)-3-(1-methylpyrr olidin-2-yl) propenamide dimaleate (called SHR1258 dimaleate for short), preparation methods thereof and pharmac
PHARMACEUTICALLY ACCEPTABLE SALT OF (E)-N-[4-[[3-CHLORO-4-(2-PYRIDYLMETHOXY)PHENYL]AMINO]-3-CYANO-7-ETHOXY-6-QUINOLYL]-3-[(2R)-1-METHYLPYRROLIDIN-2-YL]PROP-2-ENAMIDE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF
-
, (2014/01/23)
Provided as represented by formula (I) is a pharmaceutically acceptable salt of (E)-N-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl] -3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide, a preparation method therefor, and a use thereof as a therapeutic agent and especially as a protein kinase inhibitor.
