1398574-80-5

Basic information

• Product Name: C₁₅H₁₅ClN₂O₃S
• Synonyms: C₁₅H₁₅ClN₂O₃S
• CAS NO: 1398574-80-5
• Molecular Weight: 338.815
• Mol File: 1398574-80-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₅ClN₂O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₅ClN₂O₃S(1398574-80-5)
• EPA Substance Registry System: C₁₅H₁₅ClN₂O₃S(1398574-80-5)

Safety Data

• Hazardous Substances Data: 1398574-80-5(Hazardous Substances Data)

Upstream product

• 6285-05-8 4'-chloropropiophenone 
• 3878-55-5 methyl hydrogen succinate 
• 82632-77-7 2-amino-4-(4’-chlorophenyl)-5-methyl-1,3-thiazole 
• 877-37-2 2-bromo-1-(4-chlorophenyl)-1-propanone 

Downstream Products

• 438215-14-6 4-((4-(4-chlorophenyl)-5-methylthiazol-2-yl)amino)-4-oxobutanoic acid 

Relevant articles and documents

Design, synthesis and biological evaluation of thiazole- and indole-based derivatives for the treatment of type II diabetes

Present studies have shown that the lipid carrier has a significant role in several aspects of metabolic syndrome in A-FABP/ap2-deficient mice, including type 2 diabetes and atherosclerosis. 38 Thiazole- and indole-based derivatives were synthesized and investigated for their inhibitory effects on the production of LPS-stimulated TNF-α. Among them, 12b exhibited an excellent inhibitory efficiency compared to BMS309403 (95% vs. 85%) at the concentration of 10 μM and a binding affinity for ap2 with the apparent Ki values 33 nM. Oral administration of 12b at a dosage of 50 mg/kg effectively reduced the levels of plasma blood glucose, triglycerides, insulin, total cholesterol and alanine aminotransferase in high-fat/diet-induced obesity model. The results highlighted that 12b was a potent anti-diabetic agent.