139887-84-6

Basic information

• Product Name: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-4-S-[(2,2-dimethyl-1- oxopropoxy)methyl]-4-thio-
• CAS NO: 139887-84-6
• Molecular Formula: C36H40N2O8S
• Molecular Weight: 660.788
• Mol File: 139887-84-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-4-S-[(2,2-dimethyl-1- oxopropoxy)methyl]-4-thio-(CAS DataBase Reference)
• NIST Chemistry Reference: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-4-S-[(2,2-dimethyl-1- oxopropoxy)methyl]-4-thio-(139887-84-6)
• EPA Substance Registry System: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-4-S-[(2,2-dimethyl-1- oxopropoxy)methyl]-4-thio-(139887-84-6)

Safety Data

• Hazardous Substances Data: 139887-84-6(Hazardous Substances Data)

Upstream product

• 5580-20-1 2'-deoxy-4-thiouridine 
• 18997-19-8 Chloromethyl pivalate 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 139905-28-5 4-S-pivaloyloxymethyl-2'-deoxy-4-thiouridine 

Downstream Products

• 127117-78-6 2'-Deoxy-5'-O-dimethoxytrityl-4-thiouridine 
• 1054624-48-4 C₄₈H₅₅N₄O₁₆PS 
• 1053267-72-3 C₄₈H₅₅N₄O₁₆PS 
• 139887-86-8 2,2-Dimethyl-propionic acid 1-{(2R,4S,5R)-4-acetoxy-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-ylsulfanylmethyl ester 
• 139764-45-7 2,2-Dimethyl-propionic acid 1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-ylsulfanylmethyl ester 

Relevant articles and documents

Synthesis and purification of oligonucleotides containing sulfur substituted nucleobases: 4-Thiouracil, 4-thiothymine and 6-mercaptopurine

A procedure to obtain oligodeoxynucleotides containing sulfur modified nucleobases by standard application of the current phosphoramidite methodology is described as well as their purification technique.

Synthesis of Deoxydinucleoside Phosphates Containing 4-Thio Substituted Pyrimidine Nucleobases

The preparations, by the hydrogenphosphonate approach in solution, of the five pyrimidine deoxydinucleoside monophosphates 14a, 14b, 16a, 16b and 17 containing a 4-thiosubstituted pyrimidine nucleobase at either their 3'- or 5'-end are described.These syntheses were conveniently accomplished using 4-thionucleoside derivatives having their sulfur function protected by S-pivaloyloxymethylation.The behaviour of unprotected 4-thionucleoside derivatives was also investigated and they were shown to give comparable overall yields.