139892-51-6

Basic information

• Product Name: 1,3-Dioxolane, 4-(chloromethyl)-2,2-diphenyl-, (R)-
• CAS NO: 139892-51-6
• Molecular Formula: C16H15ClO2
• Molecular Weight: 274.747
• Mol File: 139892-51-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxolane, 4-(chloromethyl)-2,2-diphenyl-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolane, 4-(chloromethyl)-2,2-diphenyl-, (R)-(139892-51-6)
• EPA Substance Registry System: 1,3-Dioxolane, 4-(chloromethyl)-2,2-diphenyl-, (R)-(139892-51-6)

Safety Data

• Hazardous Substances Data: 139892-51-6(Hazardous Substances Data)

Upstream product

• 119-61-9 benzophenone 
• 57090-45-6 (2R)-3-chloro-1,2-propanediol 

Downstream Products

• 139892-52-7 Butyric acid (R)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl ester 
• 124918-09-8 (4S)-2,2-diphenyl-4-(hydroxymethyl)-1,3-dioxolane 

Relevant articles and documents

Enzymatic resolution of 2,2-disubstituted-1,3-dioxolane-4-methanol carboxylic esters

The enantioselectivity of enzymatic hydrolysis of carboxylic esters of various 1,2-ketals of glycerol has been investigated. The influence of the ketal group has been studied. A number of lipases and proteinases have been tested and the best enantioselectivity was obtained with proteinase from Aspergillus oryzae which gave an E-value of 9 with 2,2-dimethyl-1,3-dioxolane-4-methanol butanoate. Variations in the acyl part revealed that butanoyl was optimal. All hydrolysis products have been synthesised in homochiral forms from homochiral starting materials.

Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1 and 5-HT1A receptor ligand: An in vitro and computational study

In this paper, the enantiomers of (±)-1, previously studied as α1 and 5-HT1A ligands, were prepared both by resolution of the racemate and asymmetric synthesis. The enantiomeric purity and absolute configuration were determined by me