139956-01-7

Basic information

• Product Name: 2-Propen-1-one, 1-(2-benzofuranyl)-3-(4-methoxyphenyl)-
• CAS NO: 139956-01-7
• Molecular Formula: C18H14O3
• Molecular Weight: 278.307
• Mol File: 139956-01-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1-(2-benzofuranyl)-3-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-(2-benzofuranyl)-3-(4-methoxyphenyl)-(139956-01-7)
• EPA Substance Registry System: 2-Propen-1-one, 1-(2-benzofuranyl)-3-(4-methoxyphenyl)-(139956-01-7)

Safety Data

• Hazardous Substances Data: 139956-01-7(Hazardous Substances Data)

Upstream product

• 1646-26-0 1-(benzo[b]furan-2-yl)ethanone 
• 123-11-5 4-methoxy-benzaldehyde 
• 90-02-8 salicylaldehyde 

Downstream Products

• 1121775-68-5 2-[2-(4-methoxyphenyl)-1-cyclopropanecarbonyl]-benzofuran 
• 1160579-02-1 1-(benzofuran-2-yl)-3-(4-methoxyphenyl)-4-nitrobutan-1-one 

Relevant articles and documents

Rational design, synthesis and 2D-QSAR study of novel vasorelaxant active benzofuran-pyridine hybrids

Reaction of 3-aryl-1-(benzofuran-2-yl)-2-propen-1-ones 3a-c with malononitrile in the presence of sufficient amount of sodium alkoxide in the corresponding alcohol proceeds in a regioselective manner to afford 2-alkoxy-4-aryl-6-(benzofuran-2-yl)-3-pyridin

Facile one pot multicomponent synthesis of novel 4-(benzofuran-2-yl)-2-(3-(aryl/heteryl)-5-(aryl/heteryl)-4,5-dihydro-1H-pyrazol-1yl)thiazole derivatives

An efficient base catalyzed one pot multicomponent reaction of aryl/hetryl chalcones, thiosemicarbazide and 1-(benzofuran-2-yl)-2-bromoethan-1-one was developed to synthesize the novel 4-(benzofuran-2-yl)-2-(3-(aryl/heteryl)-5-(aryl/heteryl)-4,5-dihydro-1H-pyrazol-1yl)thiazole derivatives.

Synthesis of Novel Benzofuran-Gathered C-2,4,6-substituted Pyrimidine Derivatives Conjugated by Sulfonyl Chlorides: Orally Bioavailable, Selective, Effective Antioxidants and Antimicrobials Drug Candidates

In the present study, we have made an effort to develop the novel synthetic antioxidants and antimicrobials with improved potency. The novel benzofuran-gathered C-2,4,6-substituted pyrimidine derivatives 5a, 5b, 5c, 5d, 5e, 5f, 6a, 6b, 6c, 6d, 6e, 6f, 7a, 7b, 7c, 7d, 7e, 7f, 8a, 8b, 8c, 8d, 8e, 8f, 9a, 9b, 9c, 9d, 9e, 9f were synthesized by simple and efficient four-step reaction pathway. Initially, o-alkyl derivative of salicylaldehyde readily furnish corresponding 2-acetyl benzofuran 2 in good yield, upon the treatment with potassium tertiary butoxide in the presence of molecular sieves. Further, Claisen-Schmidt condensation with aromatic aldehydes via treatment with thiourea followed by coupling reaction with different sulfonyl chlorides afforded target compounds. The structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, mass, and elemental analysis and further screened for their antioxidant and antimicrobial activities. The results showed that the synthesized compounds 8b, 8e, 9b, and 9e produced significant antioxidant activity with 50% inhibitory concentration higher than that of reference, whereas compounds 7d and 7c produced dominant antimicrobial activity at concentrations 1.0 and 0.5 mg/mL compared with standard Gentamicin and Nystatin, respectively.