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140-40-9

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140-40-9 Usage

Description

2-ACETAMIDO-5-NITROTHIAZOLE is an organic compound with the chemical formula C4H4N4O2S. It is a yellow-brown solid and is known for its anti-inflammatory and antibacterial properties. It is also used as a chemotherapy drug and has been identified as a protistocide drug.

Uses

Used in Pharmaceutical Industry:
2-ACETAMIDO-5-NITROTHIAZOLE is used as an anti-inflammatory agent for its ability to reduce inflammation and alleviate pain. It is also used as a glucocorticoid, which helps to suppress the immune system and is beneficial in treating various inflammatory and autoimmune conditions.
Used in Chemotherapy:
2-ACETAMIDO-5-NITROTHIAZOLE is used as a chemotherapy drug, specifically for its role in the treatment of cancer. It works by inhibiting the growth and proliferation of cancer cells, making it a valuable component in the fight against the disease.
Used in Antibacterial Applications:
As a protistocide drug, 2-ACETAMIDO-5-NITROTHIAZOLE is used for its antibacterial activity, helping to combat bacterial infections and promote overall health.
Used in Research and Development:
Due to its unique chemical properties and potential applications, 2-ACETAMIDO-5-NITROTHIAZOLE is also used in research and development for the discovery of new drugs and therapies, particularly in the fields of oncology and infectious diseases.

Safety Profile

Poison by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of SO, and NOx,.

Purification Methods

Recrystallise acinitrazole from EtOH or AcOH. [Hurd & Wehrmeister J Am Chem Soc 71 4007 1949, Beilstein 27 III/IV 4676.]

Check Digit Verification of cas no

The CAS Registry Mumber 140-40-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 0 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 140-40:
(5*1)+(4*4)+(3*0)+(2*4)+(1*0)=29
29 % 10 = 9
So 140-40-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H5N3O3S/c1-3(9)7-5-6-2-4(12-5)8(10)11/h2H,1H3,(H,6,7,9)

140-40-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Alfa Aesar

  • (L01356)  2-Acetamido-5-nitrothiazole, 98%   

  • 140-40-9

  • 1g

  • 477.0CNY

  • Detail
  • Alfa Aesar

  • (L01356)  2-Acetamido-5-nitrothiazole, 98%   

  • 140-40-9

  • 5g

  • 1715.0CNY

  • Detail
  • Sigma-Aldrich

  • (33978)  2-Acetamido-5-nitrothiazole  VETRANAL, analytical standard

  • 140-40-9

  • 33978-100MG-R

  • 780.39CNY

  • Detail

140-40-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Acetamido-5-nitrothiazole

1.2 Other means of identification

Product number -
Other names Acetamide, N-(5-nitro-2-thiazolyl)-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:140-40-9 SDS

140-40-9Synthetic route

2-amino-5-nitro-1,3-thiazole
121-66-4

2-amino-5-nitro-1,3-thiazole

acetic anhydride
108-24-7

acetic anhydride

Nitazole
140-40-9

Nitazole

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;91%
2-acetamidothiazole
2719-23-5

2-acetamidothiazole

ethyl nitrate
625-58-1

ethyl nitrate

Nitazole
140-40-9

Nitazole

Conditions
ConditionsYield
With sulfuric acid; potassium nitrate
2-acetamidothiazole
2719-23-5

2-acetamidothiazole

Nitazole
140-40-9

Nitazole

Conditions
ConditionsYield
With sulfuric acid; nitric acid
With nitric acid; acetic anhydride
With ammonium nitrate; sulfuric acid at 20 - 30℃; for 2.5h; Yield given;
2-amino-5-nitro-1,3-thiazole
121-66-4

2-amino-5-nitro-1,3-thiazole

Nitazole
140-40-9

Nitazole

Conditions
ConditionsYield
With acetic anhydride
With pyridine
With sulfuric acid
2-acetamido-5-bromothiazole
7336-54-1

2-acetamido-5-bromothiazole

Nitazole
140-40-9

Nitazole

Conditions
ConditionsYield
With nitric acid; acetic anhydride; acetic acid
acetic anhydride
108-24-7

acetic anhydride

thiazol-2-ylamine; nitrate
57530-25-3

thiazol-2-ylamine; nitrate

Nitazole
140-40-9

Nitazole

Conditions
ConditionsYield
(i) Na2CO3, CCl4, (ii) H2SO4; Multistep reaction;
Nitazole
140-40-9

Nitazole

2-amino-5-nitro-1,3-thiazole
121-66-4

2-amino-5-nitro-1,3-thiazole

Conditions
ConditionsYield
With hydrogenchloride
Nitazole
140-40-9

Nitazole

2-bromo-propionic acid amide
5875-25-2

2-bromo-propionic acid amide

2-(2-acetylimino-5-nitro-thiazol-3-yl)-propionamide
23599-21-5

2-(2-acetylimino-5-nitro-thiazol-3-yl)-propionamide

Conditions
ConditionsYield
With sodium hydride; N,N-dimethyl-formamide
Nitazole
140-40-9

Nitazole

2-Bromo-N-(n-octyl)acetamide
5326-97-6

2-Bromo-N-(n-octyl)acetamide

2-(2-acetylimino-5-nitro-thiazol-3-yl)-N-octyl-acetamide
38922-42-8

2-(2-acetylimino-5-nitro-thiazol-3-yl)-N-octyl-acetamide

Conditions
ConditionsYield
With sodium hydride; N,N-dimethyl-formamide
Nitazole
140-40-9

Nitazole

ethyl bromoacetate
105-36-2

ethyl bromoacetate

A

N-acetyl-N-(5-nitro-thiazol-2-yl)-glycine ethyl ester
38922-43-9

N-acetyl-N-(5-nitro-thiazol-2-yl)-glycine ethyl ester

B

(2-acetylimino-5-nitro-thiazol-3-yl)-acetic acid ethyl ester
23599-22-6

(2-acetylimino-5-nitro-thiazol-3-yl)-acetic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride; N,N-dimethyl-formamide
Nitazole
140-40-9

Nitazole

4-bromobutanenitrile
5332-06-9

4-bromobutanenitrile

A

N-(3-cyano-propyl)-N-(5-nitro-thiazol-2-yl)-acetamide
39020-59-2

N-(3-cyano-propyl)-N-(5-nitro-thiazol-2-yl)-acetamide

B

4-(2-acetylimino-5-nitro-thiazol-3-yl)-butyronitrile
38922-53-1

4-(2-acetylimino-5-nitro-thiazol-3-yl)-butyronitrile

Conditions
ConditionsYield
With sodium hydride; N,N-dimethyl-formamide
Nitazole
140-40-9

Nitazole

N-(3-cyano-propyl)-N-(5-nitro-thiazol-2-yl)-acetamide
39020-59-2

N-(3-cyano-propyl)-N-(5-nitro-thiazol-2-yl)-acetamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaH, DMF
2: aq. HCl
View Scheme
Nitazole
140-40-9

Nitazole

4-[acetyl-(5-nitro-thiazol-2-yl)-amino]-butyramide
38922-63-3

4-[acetyl-(5-nitro-thiazol-2-yl)-amino]-butyramide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaH, DMF
2: aq. HCl
View Scheme
Multi-step reaction with 3 steps
1: NaH, DMF
2: aq. HCl
3: aq. HCl
View Scheme
Nitazole
140-40-9

Nitazole

4-(2-acetylimino-5-nitro-thiazol-3-yl)-butyramide
38922-54-2

4-(2-acetylimino-5-nitro-thiazol-3-yl)-butyramide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaH, DMF
2: aq. HCl
View Scheme

140-40-9Downstream Products

140-40-9Relevant articles and documents

-

Viron,Taurins

, p. 885,892 (1953)

-

-

Vavilov,G.A. et al.

, (1975)

-

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