1400-44-8Relevant articles and documents
Convergent asymmetric synthesis of (+)-aureothin employing an oxygenase-mediated resolution step
Henrot, Matthias,Richter, Martin E.A.,Maddaluno, Jacques,Hertweck, Christian,De Paolis, Micha?l
, p. 9587 - 9591 (2012)
Need an enzymatic push? The desymmetrization of α,α'-dimethoxy- γ-pyrone allows the convergent and rapid preparation of the complete carbon skeleton of (+)-aureothin (see scheme). The final step in the synthesis of the target molecule is the regiodivergen
Yamazaki
, p. 2701,2704 (1972)
Structural fine-tuning of a multifunctional cytochrome P450 monooxygenase
Zocher, Georg,Richter, Martin E. A.,Mueller, Uwe,Hertweck, Christian
supporting information; experimental part, p. 2292 - 2302 (2011/04/23)
AurH is a unique cytochrome P450 monooxygenase catalyzing the stepwise formation of a homochiral oxygen heterocycle, a key structural and pharmacophoric component of the antibiotic aureothin. The exceptional enzymatic reaction involves a tandem oxygenatio
The biomimetic synthesis of SNF4435C and SNF4435D, and the total synthesis of the polyene metabolites aureothin, N-acetyl-aureothamine and spectinabilin
Jacobsen, Mikkel F.,Moses, John E.,Adlington, Robert M.,Baldwin, Jack E.
, p. 1675 - 1689 (2007/10/03)
Full details of the biomimetic conversion of polyene metabolite spectinabilin (5) into the isomeric natural products SNF4435C (1) and SNF4435D (2) by a cascade of E/Z-isomerizations and electrocyclizations are reported. Additionally, short total syntheses