1400250-84-1

Basic information

• Product Name: C₂₃H₁₇ClN₄O₃
• Synonyms: C₂₃H₁₇ClN₄O₃
• CAS NO: 1400250-84-1
• Molecular Weight: 432.866
• Mol File: 1400250-84-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₁₇ClN₄O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₁₇ClN₄O₃(1400250-84-1)
• EPA Substance Registry System: C₂₃H₁₇ClN₄O₃(1400250-84-1)

Safety Data

• Hazardous Substances Data: 1400250-84-1(Hazardous Substances Data)

Upstream product

• 38871-41-9 2,3-dihydrobenzo-[b]-1,4-dioxine-5-carbonyl chloride 
• 153436-71-6 6-amino-4-[(3-chlorophenyl)amino]quinazoline 
• 153436-72-7 4-<(3-chlorophenyl)amino>-6-nitroquinazoline 

Relevant articles and documents

Discovery of 6-substituted 4-anilinoquinazolines with dioxygenated rings as novel EGFR tyrosine kinase inhibitors

It had been reported that some dioxygenated rings fusing with the quinazoline scaffold could lead to new EGFR inhibitors. Based on this, several kinds of oxygenated alkane quinazoline derivatives were synthetized and evaluated as EGFR inhibitors. Their antiproliferative activities were tested against four cancer cell lines: A431, MCF-7, A549, and B16-F10. Most derivatives could counteract EGF-induced EGFR phosphorylation, and their potency was comparable to the reference compound Erlotinib. The size of the fused dioxygenated ring was crucial for the biological activity and the heptatomic ring derivative 19 showed potent in vitro inhibitory activity in the enzymatic assay as well as in the cellular assay.