1400283-75-1

Basic information

• Product Name: C₂₅H₂₉N₃O₃S₂
• CAS NO: 1400283-75-1
• Molecular Weight: 483.656
• Mol File: 1400283-75-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₉N₃O₃S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₉N₃O₃S₂(1400283-75-1)
• EPA Substance Registry System: C₂₅H₂₉N₃O₃S₂(1400283-75-1)

Safety Data

• Hazardous Substances Data: 1400283-75-1(Hazardous Substances Data)

Upstream product

• 1723-00-8 (R)-(+)-pipecolic acid 
• 108481-92-1 4-(4-isopropylphenyl)thiazole-2-amine 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1- tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K v7.1 (KCNQ1) potassium channel activator

A high-throughput screen utilizing a depolarization-triggered thallium influx through KCNQ1 channels was developed and used to screen the MLSMR collection of over 300,000 compounds. An iterative medicinal chemistry approach was initiated and from this effort, ML277 was identified as a potent activator of KCNQ1 channels (EC50 = 260 nM). ML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel.