1400284-01-6

Basic information

• Product Name: C₂₀H₂₅N₃O₄S₂
• CAS NO: 1400284-01-6
• Molecular Weight: 435.568
• Mol File: 1400284-01-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₅N₃O₄S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₅N₃O₄S₂(1400284-01-6)
• EPA Substance Registry System: C₂₀H₂₅N₃O₄S₂(1400284-01-6)

Safety Data

• Hazardous Substances Data: 1400284-01-6(Hazardous Substances Data)

Upstream product

• 128453-98-5 thiomorpholine-3,4-dicarboxylic acid 4-tert-butyl ester 
• 2104-04-3 4-(4-methoxyphenyl)-1,3-thiazol-2-amine 

Relevant articles and documents

Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1- tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K v7.1 (KCNQ1) potassium channel activator

A high-throughput screen utilizing a depolarization-triggered thallium influx through KCNQ1 channels was developed and used to screen the MLSMR collection of over 300,000 compounds. An iterative medicinal chemistry approach was initiated and from this effort, ML277 was identified as a potent activator of KCNQ1 channels (EC50 = 260 nM). ML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel.