1400815-07-7

Basic information

• Product Name: N'-(1,3-benzodioxol-5-ylmethylene)-2-thiophenecarbohydrazide
• Synonyms: N'-(1,3-benzodioxol-5-ylmethylene)-2-thiophenecarbohydrazide
• CAS NO: 1400815-07-7
• Molecular Formula: C13H10N2O3S
• Molecular Weight: 274.2951
• Mol File: 1400815-07-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N'-(1,3-benzodioxol-5-ylmethylene)-2-thiophenecarbohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-(1,3-benzodioxol-5-ylmethylene)-2-thiophenecarbohydrazide(1400815-07-7)
• EPA Substance Registry System: N'-(1,3-benzodioxol-5-ylmethylene)-2-thiophenecarbohydrazide(1400815-07-7)

Safety Data

• Hazardous Substances Data: 1400815-07-7(Hazardous Substances Data)

Upstream product

• 2361-27-5 2-thienylhydrazide 
• 120-57-0 piperonal 
• 5380-42-7 thiophene-2-carboxylic acid methyl ester 
• 98-03-3 thiophene-2-carbaldehyde 

Relevant articles and documents

Antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor

Several N-acylhydrazone derivatives synthesized from safrole have been found to promote intense vasodilation and antihypertensive activity. The present work describes the synthesis and antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone (LASSBio-1027), a new analogue of the lead compound 3,4-methylenedioxybenzoyl-2-thienylhydrazone. Thoracic aortas from Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) were prepared for isometric tension recording. Noninvasive blood pressure measurements were made during 14 days of intraperitoneal (10 mg/kg) or oral (20 mg/kg) administration of LASSBio-1027. LASSBio-1027 exhibited partially endothelium-dependent vasorelaxant activity, which was attenuated in the presence of l-NAME, glibenclamide, or ZM 241385. LASSBio-1027 exhibited an antihypertensive effect in SHR during 14 days of intraperitoneal or oral administration, but did not induce a hypotensive effect in normotensive WKY rats. LASSBio-1027-induced vascular relaxation of aortas from WKY rats was mediated by the activation of A2A adenosine receptors. Docking studies and binding assays suggested that LASSBio-1027 has affinity for A 2A and A3 adenosine receptors. This new N-acylhydrazone derivative represents a potential strategy for the treatment of arterial hypertension.