140128-58-1

Basic information

• Product Name: (6R,7R)-7-[2-(2-tert-Butoxycarbonylamino-thiazol-4-yl)-acetylamino]-8-oxo-3-(1-trityl-1H-[1,2,3]triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
• CAS NO: 140128-58-1
• Molecular Weight: 994.252
• Mol File: 140128-58-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (6R,7R)-7-[2-(2-tert-Butoxycarbonylamino-thiazol-4-yl)-acetylamino]-8-oxo-3-(1-trityl-1H-[1,2,3]triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (6R,7R)-7-[2-(2-tert-Butoxycarbonylamino-thiazol-4-yl)-acetylamino]-8-oxo-3-(1-trityl-1H-[1,2,3]triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester(140128-58-1)
• EPA Substance Registry System: (6R,7R)-7-[2-(2-tert-Butoxycarbonylamino-thiazol-4-yl)-acetylamino]-8-oxo-3-(1-trityl-1H-[1,2,3]triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester(140128-58-1)

Safety Data

• Hazardous Substances Data: 140128-58-1(Hazardous Substances Data)

Upstream product

• 1026198-12-8 (6R,7R)-8-Oxo-7-phenylacetylamino-3-(1-trityl-1H-[1,2,3]triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 140128-30-9 diphenylmethyl 7β-phenylacetamido-3-(1H-1,2,3-triazol-4-yl)thiomethylthio-3-cephem-4-carboxylate 
• 92096-37-2 benzhydryl (6R,7R)-7β-[(phenylacetyl)amino]-3-[(methylsulfonyl)oxy]-3-cephem-4-carboxylate 
• 76-83-5 trityl chloride 
• 89336-46-9 2-{2[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl}acetic acid 
• 1026460-46-7 diphenylmethyl 7β-amino-3-<1-triphenylmethyl-1H-1,2,3-triazol-4-yl>thiomethylthio-3-cephem-4-carboxylate 

Relevant articles and documents

Orally active cephalosporins. IV. Synthesis, antibacterial activity and oral absorption of 3-(1H-1,2,3-triazol-4-yl)thiomethylthio-cephalosporins

The synthesis, antibacterial activity and oral absorption of 3-(1H-1,2,3-triazol-4-yl)thiomethylthio-3-cephem-4-carboxylic acids with various C-7 side chains (2) are described. The (1H-1,2,3-triazol-4-yl)thiomethylthio C-3 side chain was found to be an effective substituent for good oral absorption of cephalosporins with some C-7 side chains.