1401414-24-1

Basic information

• Product Name: C₃₇H₅₀BrNO₄
• Synonyms: C₃₇H₅₀BrNO₄
• CAS NO: 1401414-24-1
• Molecular Weight: 652.712
• Mol File: 1401414-24-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₃₇H₅₀BrNO₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₇H₅₀BrNO₄(1401414-24-1)
• EPA Substance Registry System: C₃₇H₅₀BrNO₄(1401414-24-1)

Safety Data

• Hazardous Substances Data: 1401414-24-1(Hazardous Substances Data)

Upstream product

• 49815-49-8 3-hydroxyimino-olean-12-en-28-oic acid 
• 586-75-4 4-chlorobenzoyl chloride 
• 508-02-1 Oleanolic acid 
• 25499-90-5 3-epioleanolic acid 
• 17990-42-0 Oleanonsaeure 
• 586-76-5 4-Bromobenzoic acid 

Relevant articles and documents

Synthesis and bioactivities evaluation of oleanolic acid oxime ester derivatives as α-glucosidase and α-amylase inhibitors

Different oleanolic acid (OA) oxime ester derivatives (3a-3t) were designed and synthesised to develop inhibitors against α-glucosidase and α-amylase. All the synthesised OA derivatives were evaluated against α-glucosidase and α-amylase in?vitro. Among them, compound 3a showed the highest α-glucosidase inhibition with an IC50 of 0.35 μM, which was ～1900 times stronger than that of acarbose, meanwhile compound 3f exhibited the highest α-amylase inhibitory with an IC50 of 3.80 μM that was ～26 times higher than that of acarbose. The inhibition kinetic studies showed that the inhibitory mechanism of compounds 3a and 3f were reversible and mixed types towards α-glucosidase and α-amylase, respectively. Molecular docking studies analysed the interaction between compound and two enzymes, respectively. Furthermore, cytotoxicity evaluation assay demonstrated a high level of safety profile of compounds 3a and 3f against 3T3-L1 and HepG2 cells.Highlights Oleanolic acid oxime ester derivatives (3a–3t) were synthesised and screened against α-glucosidase and α-amylase. Compound 3a showed the highest α-glucosidase inhibitory with IC50 of 0.35 μM. Compound 3f presented the highest α-amylase inhibitory with IC50 of 3.80 μM. Kinetic studies and in silico studies analysed the binding between compounds and α-glucosidase or α-amylase.