1401518-68-0

Basic information

• Product Name: 1-(pyridin-2-yl)-2-{4-(trifluoromethyl)phenyl}-1H-indole
• Synonyms: 1-(pyridin-2-yl)-2-{4-(trifluoromethyl)phenyl}-1H-indole
• CAS NO: 1401518-68-0
• Molecular Weight: 338.332
• Mol File: 1401518-68-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-(pyridin-2-yl)-2-{4-(trifluoromethyl)phenyl}-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(pyridin-2-yl)-2-{4-(trifluoromethyl)phenyl}-1H-indole(1401518-68-0)
• EPA Substance Registry System: 1-(pyridin-2-yl)-2-{4-(trifluoromethyl)phenyl}-1H-indole(1401518-68-0)

Safety Data

• Hazardous Substances Data: 1401518-68-0(Hazardous Substances Data)

Upstream product

• 455-13-0 4-Iodobenzotrifluoride 
• 3419-91-8 N-(2-pyridyl)indole 
• 591-50-4 iodobenzene 
• 504-29-0 2-aminopyridine 
• 6631-37-4 2-(phenylamino)pyridine 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 62-53-3 aniline 
• 109-04-6 2-bromo-pyridine 
• 120-72-9 indole 
• 34857-67-5 4-(trifluoromethyl)phenyl dimethylcarbamate 

Relevant articles and documents

Copper-Catalyzed Direct Arylation of Indoles and Related (Hetero)arenes: A Ligandless and Solvent-free Approach

A ligandless and solvent-free copper-catalyzed method for the regioselective C?H bond arylation of indoles and related heteroarenes is reported. The use of CuCl efficiently catalyzes the direct coupling of diverse heteroarenes with aryl iodides via chelation-assistance. This reaction could tolerate sensitive and structurally diverse functionalities, including halides, ethers, thioethers, amines, indolyl, pyrrolyl and carbazolyl groups. The directing group, 2-pyridinyl can be smoothly removed to generate C-2 arylated free-NH indoles, and the arylated indoles can further be functionalized into Tryptamine derivatives. Preliminary mechanistic study revealed a radical pathway for the arylation reaction. (Figure presented.).

Ruthenium-catalyzed synthesis of indole derivatives from: N -aryl-2-aminopyridines and alpha-carbonyl sulfoxonium ylides

Indole is a ubiquitous structural motif with important applications in many areas of chemistry. Given this, a simple and efficient Ru(ii)-catalyzed synthesis of indole via intermolecular annulation of N-aryl-2-aminopyridines and sulfoxonium ylides was proposed and accomplished. Excellent selectivity and good functional group tolerance of this transformation were observed. This protocol provides easy access to a wide variety of useful indoles in the presence of a commercially available [Ru(p-cymene)Cl2]2 catalyst. A possible mechanism for the reaction pathway was also proposed. More importantly, this reaction will offer a useful method for the construction of enantioenriched indole frameworks.

Synthesis of 2-Arylindoles through Pd(II)-Catalyzed Cyclization of Anilines with Vinyl Azides

Vinly azides are featured as electrophiles, nucleophiles, and radical acceptors in synthetic chemistry and have emerged as rapid and versatile synthons in the preparation of N-heterocyclic systems. Herein, a novel approach to 2-arylindoles via Pd(II)-catalyzed cyclization reaction of anilines with vinyl azides has been achieved, which furnishes the versatile 2-arylindoles with high efficieny and excellent regioselectivity.