140170-82-7

Basic information

• Product Name: Butanoic acid, 2-amino-, ethyl ester, (R)-
• CAS NO: 140170-82-7
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.175
• Mol File: 140170-82-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-amino-, ethyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-amino-, ethyl ester, (R)-(140170-82-7)
• EPA Substance Registry System: Butanoic acid, 2-amino-, ethyl ester, (R)-(140170-82-7)

Safety Data

• Hazardous Substances Data: 140170-82-7(Hazardous Substances Data)

Upstream product

• 126861-99-2 2-(Benzhydrylidene-amino)-butyric acid ethyl ester 
• 64-17-5 ethanol 
• 2623-91-8 (R)-2-aminobutyric acid 
• 140170-76-9 (R)-2-[Benzyl-((R)-2-hydroxy-1-phenyl-ethyl)-amino]-butyric acid ethyl ester 
• 67607-42-5 R-(-)-2-amino-n-butyric acid hydrochloride 

Downstream Products

• 5856-63-3 (2R)-2-aminobutan-1-ol 

Relevant articles and documents

Orthogonally Protected Sch?llkopf's Bis-lactim Ethers for the Asymmetric Synthesis of α-Amino Acid Derivatives and Dipeptide Esters

Alkylation of the aza-enolates of orthogonally protected chiral bis-lactim ethers with electrophiles proceeds with good levels of diastereocontrol to afford trans-alkylated adducts that can be efficiently deprotected via hydrolysis/hydrogenation procedures to afford non-proteinogenic α-amino acid or dipeptide ester derivatives.

Design and synthesis of a s-triazene based asymmetric organocatalyst and its application in enantioselective alkylation

A very efficient chiral organocatalyst was prepared from the readily available cyanuric chloride. The asymmetric catalyst exhibited a highly enantioselective catalytic performance for the alkylation of a glycinate Schiff base, which provides a useful procedure for the enantioselective synthesis of structurally diverse natural and unnatural α-alkyl-α-amino acids.

A New Chiral Glycine Synthon. Synthesis, X-Ray Structure of (-)-(2S,4R)-2-Ethoxycarbonyl-4-phenyl-1,3-oxazolidine and Diastereoselective Nucleophilic Ring Opening to (R)-Ethyl α-Amino Carboxylates.

Condensation of (R)-N-benzyl-2-phenylglycinol 1 with the methyl hemiacetal of ethyl glyoxylate leads to (2S,4R)-2-ethoxycarbonyl-4-phenyl-1,3-oxazolidine 2 as the major product, obtained as a pure enantiomer after column chromatography.Compound 2 is stereoselectively cleaved by dialkylzinc reagents, prepared from alkylmagnesium iodides and ZnCl2, with moderate to good d.e. (72-94 percent).These compounds, after separation by column chromatography and debenzylation by hydrogenolysis in the presence of 10percent Pd on carbon, lead to enantiomerically pure ethyl α-amino carboxylates with good chemical yields. Key words: Chiral Oxazolidines, alpha-amino Esters, Chiral Glycine Synthon, Ring Opening, Asymmetric Synthesis