1401882-30-1Relevant articles and documents
Ligand-Free RuCl3-Catalyzed Alkylation of Methylazaarenes with Alcohols
Feng, Tong-Yu,Li, Hong-Xi,Young, David James,Lang, Jian-Ping
, p. 4113 - 4120 (2017/04/28)
RuCl3 efficiently catalyzes the alkylation of methylquinolines, methylpyridines, 2-methyl-benzooxazoles, and 2-methyl-quinoxalines with alkyl- or aryl-alcohols as alkylating agents. This synthetically useful and atom economical transformation does not require additional ligands. The mechanistic study indicated the alkylation reaction underwent a stepwise transfer hydrogenation, aldol condensation, and hydrogenation reaction pathway.