1402041-63-7Relevant articles and documents
Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX
Elkady, Mahmoud,Niess, Raimund,Bauer, Julia,Luderer, Susann,Ambrosi, Giulia,Laufer, Stefan A.,Schaible, Anja M.,Werz, Oliver
supporting information, p. 8958 - 8962,5 (2020/09/16)
mPGES-1 is a promising target for development of new anti-inflammatory drugs. We aimed to create mPGES-1 inhibitors by modifying the structure of NSAIDs by replacing the carboxylic acid functionality by sulfonamide moieties. Compounds were also tested for