1402049-25-5

Basic information

• Product Name: tert-butyl 4-(6-(2-(2-methoxy-4-(methoxycarbonyl)phenyl)-4-oxothiazolidin-3-yl)pyridin-3-yl)piperazine-1-carboxylate
• Synonyms: tert-butyl 4-(6-(2-(2-methoxy-4-(methoxycarbonyl)phenyl)-4-oxothiazolidin-3-yl)pyridin-3-yl)piperazine-1-carboxylate
• CAS NO: 1402049-25-5
• Molecular Weight: 528.629
• Mol File: 1402049-25-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(6-(2-(2-methoxy-4-(methoxycarbonyl)phenyl)-4-oxothiazolidin-3-yl)pyridin-3-yl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(6-(2-(2-methoxy-4-(methoxycarbonyl)phenyl)-4-oxothiazolidin-3-yl)pyridin-3-yl)piperazine-1-carboxylate(1402049-25-5)
• EPA Substance Registry System: tert-butyl 4-(6-(2-(2-methoxy-4-(methoxycarbonyl)phenyl)-4-oxothiazolidin-3-yl)pyridin-3-yl)piperazine-1-carboxylate(1402049-25-5)

Safety Data

• Hazardous Substances Data: 1402049-25-5(Hazardous Substances Data)

Upstream product

• 571189-16-7 4-(6-nitropyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 39856-50-3 5-bromo2-nitropyridine 
• 571188-59-5 tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 
• 68-11-1 mercaptoacetic acid 
• 74733-24-7 4-formyl-3-methoxybenzoic acid methyl ester 

Downstream Products

• 1615687-54-1 methyl 3-methoxy-4-(4-oxo-3-(5-(piperazin-1-yl)pyridin-2-yl)thiazolidin-2-yl)benzoate 
• 1615687-44-9 methyl 3-methoxy-4-(3-(5-(4-(4-methoxyphenylsulfonyl)piperazin-1-yl)pyridin-2-yl)-4-oxothiazolidin-2-yl)benzoate 
• 1615687-45-0 methyl 3-methoxy-4-(3-(5-(4-(4-nitrophenylsulfonyl)piperazin-1-yl)pyridin-2-yl)-4-oxothiazolidin-2-yl)benzoate 
• 1615687-46-1 methyl 4-(3-(5-(4-(mesitylsulfonyl)piperazin-1-yl)pyridin-2-yl)-4-oxothiazolidin-2-yl)-3-methoxybenzoate 
• 1615687-47-2 methyl 4-(3-(5-(4-(2,5-dichlorophenylsulfonyl)piperazin-1-yl)pyridin-2-yl)-4-oxothiazolidin-2-yl)-3-methoxybenzoate 
• 1615687-49-4 methyl 4-(3-(5-(4-(4-fluorophenylsulfonyl)piperazin-1-yl)pyridin-2-yl)-4-oxothiazolidin-2-yl)-3-methoxybenzoate 
• 1615687-50-7 methyl 3-methoxy-4-(3-(5-(4-(3-methylbenzyl)piperazin-1-yl)pyridin-2-yl)-4-oxothiazolidin-2-yl)benzoate 
• 1615687-51-8 methyl 3-methoxy-4-(4-oxo-3-(5-(4-(3,4,5-trimethoxybenzyl)piperazin-1-yl)pyridin-2-yl)thiazolidin-2-yl)benzoate 
• 1615687-52-9 methyl 3-methoxy-4-(3-(5-(4-(3-nitrobenzyl)piperazin-1-yl)pyridin-2-yl)-4-oxothiazolidin-2-yl)benzoate 
• 1615687-53-0 methyl 4-(3-(5-(4-(3,4-dichlorobenzyl)piperazin-1-yl)pyridin-2-yl)-4-oxothiazolidin-2-yl)-3-methoxybenzoate 

Relevant articles and documents

Synthesis and antiproliferative effect of novel 4-thiazolidinone-, pyridine- and piperazine-based conjugates on human leukemic cells

The present work reveals the synthesis and antiproliferative effect of a series of 2, 3 disubstituted 4-thiazolidinone analogues on human leukemic cells. The chemical structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and mass spectral analysis. Compound methyl 3-methoxy-4-(4-oxo-3-(5-(piperazin-1-yl)pyridin-2-yl)thiazolidin-2-yl) benzoate (5) displayed potent activity (IC509.71, 15.24 and 19.29 μM) against Nalm6, K562, Jurkat cells. Cell cycle analysis and mitochondrial membrane potential further confirmed that compound 5 is cytotoxic and able to induce cell death.