1402055-32-6

Basic information

• Product Name: 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-4-oxo-2-(phenylamino)-4,5-dihydrofuran-3-carboxylic acid
• Synonyms: 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-4-oxo-2-(phenylamino)-4,5-dihydrofuran-3-carboxylic acid
• CAS NO: 1402055-32-6
• Molecular Weight: 347.33
• Mol File: 1402055-32-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-4-oxo-2-(phenylamino)-4,5-dihydrofuran-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-4-oxo-2-(phenylamino)-4,5-dihydrofuran-3-carboxylic acid(1402055-32-6)
• EPA Substance Registry System: 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-4-oxo-2-(phenylamino)-4,5-dihydrofuran-3-carboxylic acid(1402055-32-6)

Safety Data

• Hazardous Substances Data: 1402055-32-6(Hazardous Substances Data)

Upstream product

• 1402055-11-1 ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-4-oxo-2-(phenylamino)-4,5-dihydrofuran-3-carboxylate 
• 58337-16-9 ethyl 4,5-dihydro-4-oxo-2-(phenylamino)-3-furancarboxylate 
• 4649-09-6 1H-pyrrolo[2,3-b]pyridin-3-carbaldehyde 

Relevant articles and documents

FURANONE DERIVATES AND METHODS OF USE THEREOF

Herein disclosed are compounds, compositions, kits, and methods of treating cancers using 7-azaindolyl furanone/thiophene derivatives. These derivatives inhibit serine-threonine kinase Cdc7, a recognized anticancer target affecting DNA replication. Further, the compounds disclosed herein possess potent inhibitory activity in the presence of adenosine triphosphate (ATP), demonstrate significant kinase selectivity, and offer advantages over known Cdc7 inhibitors with prolonged half-life and inhibitory effects.

NOVEL FURANONE DERIVATIVE

To provide a novel furanone derivative, and a medicine including the same. The furanone derivative is represented by the formula (I): wherein A represents —COOR1 or a hydrogen atom; R1 represents a hydrogen atom, an optionally substituted hydrocarbon grou