1402836-42-3Relevant articles and documents
Facile synthesis for benzo-1,4-oxazepine derivatives by tandem transformation of C-N coupling/C-H carbonylation
Zhao, Xiaojia,Zhang, Jiong,Zheng, Zeqin,Xu, Runsheng
, (2017/01/24)
A tandem transformation of C-N coupling/C-H carbonylation has been developed for the synthesis of benzo-1,4-oxazepine pharmaceutically derivatives. Notably, this reaction was accomplished by various phenylamine with ally halides under carbon dioxide atmosphere employing 2-(2-dimethylamino-vinyl)-1H-inden-1-olcatalyzed. Furthermore, under the optimized conditions, various benzo-1,4-oxazepine derivatives were obtained in good yields. Finally, a plausible CuI/CuIII mechanism of C-N coupling/C-H carbonylation transformation was proposed.