1403-17-4 Usage
Description
CANDICIDIN (200 MG) is a macrocyclic heptaene antifungal complex derived from Streptomyces griseus, a soil-dwelling bacterium. It was first isolated by Lechevalier and colleagues in 1953 and consists of four analogues: A, B, C, and D, with candicidin D being the primary component. This antifungal agent is particularly effective against Candida albicans, a common fungus responsible for various infections. CANDICIDIN (200 MG) works by binding to ergosterol, a vital component of the fungal cell membrane, which leads to the disruption of the membrane and ultimately, the death of the fungal cell.
Uses
Used in Pharmaceutical Industry:
CANDICIDIN (200 MG) is used as an antifungal agent for the treatment of vaginal candidiasis, a common fungal infection that affects the female genital tract. It is particularly effective against Candida albicans, the primary causative agent of this condition.
Used in Clinical Settings:
In clinical practice, CANDICIDIN (200 MG) is utilized to combat fungal infections, particularly those caused by Candida albicans. Its high efficacy against this fungus makes it a valuable tool in the treatment of various fungal infections, including those that are resistant to other antifungal medications.
Brand Name:
CANDICIDIN (200 MG) is commercially available under the brand name Vanobid, manufactured by Sanofi Aventis. This brand name product ensures the quality and consistency of the antifungal agent, providing healthcare professionals and patients with a reliable treatment option for fungal infections.
Originator
Candeptin,Schmidt,US,1964
Manufacturing Process
Hubert Lechevalier et al were the first to describe "Candicidin, a New
Antifungal Antibiotic," in Mycologia XLV, No. 2, 155-171, March-April 1953.
They produced candicidin by growing a culture of the organism streptomyces
griseus No. 3570 on a yeast-glucose medium, isolating a "crude candicidin"
from the resulting broth and purifying it. An improved extraction and
purification method is described in US Patent 2,872,373 and is shown in the
flow diagram below.Another extraction and separation process is described in US Patent
2,992,162.
Check Digit Verification of cas no
The CAS Registry Mumber 1403-17-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,0 and 3 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1403-17:
(6*1)+(5*4)+(4*0)+(3*3)+(2*1)+(1*7)=44
44 % 10 = 4
So 1403-17-4 is a valid CAS Registry Number.
InChI:InChI=1/C59H84N2O18/c1-35-18-15-13-11-9-7-5-6-8-10-12-14-16-21-47(78-59-56(74)54(61)55(73)38(4)77-59)33-51(71)53(58(75)76)50(70)31-46(67)30-45(66)29-44(65)28-43(64)27-41(62)19-17-20-42(63)32-52(72)79-57(35)37(3)26-36(2)48(68)34-49(69)39-22-24-40(60)25-23-39/h5-16,18,21-25,35-38,43-45,47-48,50-51,53-57,59,64-66,68,70-71,73-74H,17,19-20,26-34,60-61H2,1-4H3,(H,75,76)/b6-5+,9-7+,10-8+,13-11+,14-12+,18-15+,21-16+/t35?,36?,37?,38-,43?,44?,45?,47?,48?,50?,51?,53?,54+,55-,56+,57?,59?/m1/s1
