1403-36-7 Usage
Description
CHAETOMIN is an organic heteropentacyclic compound belonging to the class of epipolythiodioxopiperazine. It is derived from Chaetomium globosum and Farrowia seminuda, and it possesses immunosuppressive activity.
Uses
Used in Pharmaceutical Industry:
CHAETOMIN is used as an immunosuppressive agent for its ability to suppress the immune system. This property makes it a potential candidate for the treatment of various conditions where immune system modulation is required, such as autoimmune diseases or organ transplantation.
Used in Research Applications:
CHAETOMIN is also used in research settings to study the effects of immunosuppression on various biological processes and to develop new therapeutic strategies for immune-related disorders.
Biochem/physiol Actions
Chetomin is a natural metabolite produced by several species of the genus Chaetomium. Chetomin is an epidithiodioxopiperazine known to disrupt the hypoxia-inducible factor (HIF) pathway. Chetomin blocks the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Disrupting the ability of tumors to adapt to hypoxia leads to decreased tumor growth and can serve as an antitumor stratagy. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes.
Check Digit Verification of cas no
The CAS Registry Mumber 1403-36-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,0 and 3 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1403-36:
(6*1)+(5*4)+(4*0)+(3*3)+(2*3)+(1*6)=47
47 % 10 = 7
So 1403-36-7 is a valid CAS Registry Number.
InChI:InChI=1/C31H30N6O6S4/c1-33-25(42)30(15-38)34(2)23(40)28(33,44-46-30)12-17-13-36(21-11-7-4-8-18(17)21)27-14-29-24(41)35(3)31(16-39,47-45-29)26(43)37(29)22(27)32-20-10-6-5-9-19(20)27/h4-11,13,22,32,38-39H,12,14-16H2,1-3H3/t22-,27+,28+,29+,30+,31+/m1/s1