14036-96-5

Basic information

• Product Name: 3-BROMO-6-METHOXYQUINOLINE
• Synonyms: 3-BROMO-6-METHOXYQUINOLINE;Quinoline, 3-broMo-6-Methoxy-
• CAS NO: 14036-96-5
• Molecular Formula: C₁₀H₈BrNO
• Molecular Weight: 238.09
• Mol File: 14036-96-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 318.3°C at 760 mmHg
• Flash Point: 146.3°C
• Appearance: /
• Density: 1.516g/cm³
• Vapor Pressure: 0.000681mmHg at 25°C
• Refractive Index: 1.64
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.57±0.14(Predicted)
• CAS DataBase Reference: 3-BROMO-6-METHOXYQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-6-METHOXYQUINOLINE(14036-96-5)
• EPA Substance Registry System: 3-BROMO-6-METHOXYQUINOLINE(14036-96-5)

Safety Data

• Hazardous Substances Data: 14036-96-5(Hazardous Substances Data)

Usage

General Description

3-Bromo-6-methoxyquinoline is a synthetic, halogenated quinoline with potential anti-infective properties. It is a methoxyquinoline and a bromoquinoline, which contains a quinoline substituted by a bromo group at position 3 and a methoxy group at position 6. This chemical compound is brown in color and is presented in crystalline powder form. It is soluble in DMSO and ethanol, but insoluble in water. It is used mainly in pharmaceutical and chemical research, the production of dyes and other chemicals. It is known to be hazardous, causing skin and eye irritation, stains on skin and clothes, and harmful if swallowed or inhaled. It should be handled with caution and proper protective equipment to minimize risks.

InChI:InChI=1/C10H8BrNO/c1-13-9-2-3-10-7(5-9)4-8(11)6-12-10/h2-6H,1H3

Upstream product

• 5263-87-6 6-methoxy quinoline 
• 13669-57-3 3-bromo-6-hydroxyquinoline 
• 74-88-4 methyl iodide 
• 24306-33-0 methyl quinolin-6-ylethanoate 
• 1022151-47-8 3-bromoquinolin-6-yl acetate 
• 580-16-5 6-hydroxyquinoline 

Downstream Products

• 29507-86-6 3-amino-6-methoxyquinoline 

Relevant articles and documents

2'-(QUINOLIN-3-YL)-5',6'-DIHYDROSPIRO[AZETIDINE-3,4'-PYRROLO[1,2-B]PYRAZOLE]-1-CARBOXYLATE DERIVATIVES AND RELATED COMPOUNDS AS MAP4K1 (HPK1) INHIBITORS FOR THE TREATMENT OF CANCER

The present invention relates to Map4K1 inhibitors of formula (I), to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, respectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients. The present invention further relates to the use, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of protein inhibitors in benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, in neurodegenerative disorders, in inflammatory disorders, in atherosclerotic disorders and in male fertility control.

Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains

A series of quinoylalkyl side chains was designed and synthesized, followed by introduction into ketolides by coupling with building block 6 or 32. The corresponding targets 7a–n, 33b, and 33e were tested for their in vitro activities against a series of macrolide-sensitive and macrolide-resistant pathogens. Some of them showed a similar antibacterial spectrum and comparable activity to telithromycin. Among them, two C2-F ketolides, compounds 33b and 33e, displayed excellent activities against macrolide-sensitive and macrolide-resistant pathogens.

INTERMOLECULAR C-H SILYLATION OF UNACTIVATED ARENES

Reaction mixtures for silvlating arene substrates and methods of using such reaction mixtures to silyiate the arene substrates are provided. Exemplary reaction mixtures include the arene substrate, a liganded metal catalyst, a hydrogen acceptor and an organic solvent. The reaction conditions allow for diverse substituents on the arene substrate.