1403873-48-2

Basic information

• Product Name: 2-(4-fluorophenyl)-1-methylindolizine-3-carbonitrile
• Synonyms: 2-(4-fluorophenyl)-1-methylindolizine-3-carbonitrile
• CAS NO: 1403873-48-2
• Molecular Weight: 250.275
• Mol File: 1403873-48-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)-1-methylindolizine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-1-methylindolizine-3-carbonitrile(1403873-48-2)
• EPA Substance Registry System: 2-(4-fluorophenyl)-1-methylindolizine-3-carbonitrile(1403873-48-2)

Safety Data

• Hazardous Substances Data: 1403873-48-2(Hazardous Substances Data)

Upstream product

• 64636-81-3 N-(cyanomethyl)pyridinium bromide 

Relevant articles and documents

A modular synthesis of polysubstituted indolizines

The N-alkylation of pyridines with cyanohydrin triflates or α-halonitriles furnishes 1-(1-cyanoalkyl)pyridinium salts that can react with nitroolefins under basic conditions to furnish polysubstituted indolizines. Overall, the indolizine core can be constructed from a pyridine, two aldehydes, and a nitroalkane, and no undesired functional groups remain in the products. When bromoacetonitrile was used for the N-alkylation, indolizine-3-carbonitriles were obtained instead. The pyridine component may be replaced by other azines, giving rise to related heterocyclic systems. Polysubstituted indolizines were synthesized through [3+2] cycloaddition of nitroalkenes with pyridinium ylides. In contrast to previous reports of 1,3-dipolar cycloadditions, in this work no electron-deficient groups remain in the products. Copyright