1404074-27-6

Basic information

• Product Name: BFM₂-(D)-DTTA
• Synonyms: BFM₂-(D)-DTTA
• CAS NO: 1404074-27-6
• Molecular Weight: 823.715
• Mol File: 1404074-27-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: BFM₂-(D)-DTTA(CAS DataBase Reference)
• NIST Chemistry Reference: BFM₂-(D)-DTTA(1404074-27-6)
• EPA Substance Registry System: BFM₂-(D)-DTTA(1404074-27-6)

Safety Data

• Hazardous Substances Data: 1404074-27-6(Hazardous Substances Data)

Upstream product

• 32634-68-7 (2S,3S)-di-4-toluoyltartaric acid 
• 171338-27-5 [2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 

Relevant articles and documents

NOVEL INTERMEDIATES FOR THE PREPARATION OF HIGHLY PURE APREPITANT OR FOSAPREPITANT

The invention provides a salt, preferably in crystalline form, of (2R,3S)-2-[(R)-1-(3,5-Bis- trifluoromethylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine (BFM2) with a Ο,Ο'-substituted tartaric acid derivative. Furthermore, a composition comprising said salt is provided. In another embodiment, a process for the preparation of said salt or said composition is provided. In a further embodiment, a process for the preparation of aprepitant or fosaprepitant is provided. One embodiment refers to the use of a salt or a composition according to the invention for the preparation of aprepitant or fosaprepitant. A further embodiment refers to aprepitant or fosaprepitant obtained or obtainable according to the process according to the invention. A further embodiment refers to a composition comprising aprepitant or fosaprepitant obtained or obtainable according to the process of the invention, preferably for use as a medicament (Formula (A)).