1404118-68-8

Basic information

• Product Name: N-[5-bromo-6-(4-cyano-2,6-dimethylphenoxy)-2-(4-cyano-phenylamino)pyrimidin-4-yl]-benzamide
• Synonyms: N-[5-bromo-6-(4-cyano-2,6-dimethylphenoxy)-2-(4-cyano-phenylamino)pyrimidin-4-yl]-benzamide
• CAS NO: 1404118-68-8
• Molecular Weight: 539.391
• Mol File: 1404118-68-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-[5-bromo-6-(4-cyano-2,6-dimethylphenoxy)-2-(4-cyano-phenylamino)pyrimidin-4-yl]-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[5-bromo-6-(4-cyano-2,6-dimethylphenoxy)-2-(4-cyano-phenylamino)pyrimidin-4-yl]-benzamide(1404118-68-8)
• EPA Substance Registry System: N-[5-bromo-6-(4-cyano-2,6-dimethylphenoxy)-2-(4-cyano-phenylamino)pyrimidin-4-yl]-benzamide(1404118-68-8)

Safety Data

• Hazardous Substances Data: 1404118-68-8(Hazardous Substances Data)

Upstream product

• 1398507-07-7 4-(4-amino-6-hydroxy-pyrimidin-2-ylamino)-benzonitrile 
• 1404118-66-6 N-[6-chloro-2-(4-cyanophenylamino)pyrimidin-4-yl]benzamide 
• 1398507-08-8 4-((4-amino-6-chloropyrimidin-2-yl)amino)benzonitrile 
• 5637-42-3 1-(4-cyanophenyl)guanidine 
• 1404118-67-7 N-[5-bromo-6-chloro-2-(4-cyanophenylamino)-pyrimidin-4-yl]-benzamide 
• 4198-90-7 3,5-dimethyl-4-hydroxybenzonitrile 

Downstream Products

• 269055-15-4 etravirine 

Relevant articles and documents

PROCESS FOR THE PRODUCTION OF ETRAVIRINE

A novel process for the preparation of Etravirine comprises the condensing of ethyl cyanoacetate with N-cyanophenylguanidine to obtain an —OH compound of formula (II), which is further converted to a leaving group of formula (III). The compound of formula (III) is optionally protected and brominated to yield compound of formula (IV). The condensation of formula (IV) with 3,5-dimethyl-4-hydroxybenzonitrile yields a compound of formula (VI), and an optional deprotection of the compound of formula (VI) results in Etravirine.