14044-48-5Relevant articles and documents
Color tuning associated with heteroleptic cyclometalated Ir(iii) complexes: Influence of the ancillary ligand
Chang, Chau-Jiun,Yang, Cheng-Han,Chen, Kellen,Chi, Yun,Shu, Ching-Fong,Ho, Mei-Lin,Yeh, Yu-Shan,Chou, Pi-Tai
, p. 1881 - 1890 (2007)
We report the preparation of a series of new heteroleptic Ir(iii) metal complexes chelated by two cyclometalated 1-(2,4-difluorophenyl)pyrazole ligands (dfpz)H and a third ancillary bidentate ligand (L^X). Such an intricate design lies in a core concept t
Iodine-catalyzed Csp3-H functionalization of methylhetarenes: One-pot synthesis and cytotoxic evaluation of heteroarenyl-benzimidazoles and benzothiazole
Baig, Mirza Feroz,Shaik, Siddiq Pasha,Nayak, V. Lakshma,Alarifi, Abdullah,Kamal, Ahmed
, p. 4039 - 4043 (2017)
An efficient one-pot synthetic procedure has been developed for the preparation of heteroarenyl-benzimidazoles via oxidative Csp3-H functionalization with o-phenylenediamine using I2-DMSO in open air from easily available starting materials. Based on a logical plan a spectrum of multi fundamental reactions like iodination, Kornblum oxidation and amination were brought into one-pot. By using this simple method a library of heteroarenyl-benzimidazoles derivatives (3a–t and 5a–g) and heteroarenyl-benzothiazole (3u) have been synthesized in good to excellent yield and screened for their cytotoxicity against a group of four human cancer cell lines. Among them 3h, 3q and 5b showed significant cytotoxic activities with an IC50 of 1.69, 1.62 and 2.81 μM respectively against lung cancer (A549) cell line.[Figure presented]
DNA targeting half sandwich Ru(ii)-: P-cymene-N^N complexes as cancer cell imaging and terminating agents: Influence of regioisomers in cytotoxicity
Mondal, Ashaparna,Sen, Utsav,Roy, Nilmadhab,Muthukumar, Venkatesan,Sahoo, Suban Kumar,Bose, Bipasha,Paira, Priyankar
, p. 979 - 997 (2021)
For diagnosing and annihilating cancer in the human body, herein, we have adopted a one pot convenient synthetic protocol to synthesize a library of half sandwich Ru(ii)-p-cymene-N^N complexes under continuous sonication and isolated their regioisomers by
Highly selective and effective mercury(ii) fluorescent sensors
Hu, Jinghan,Li, Jianbin,Qi, Jing,Chen, Juanjuan
, p. 843 - 848 (2015)
A novel mercury non-sulfur and simple fluorescent chemosensor L based on the benzimidazole group and quinoline group as the fluorescence signal group has been designed and synthesized. The receptor could instantly detect the Hg2+ cation over other cations such as Fe3+, Ag+, Ca2+, Cu2+, Co2+, Ni2+, Cd2+, Pb2+, Zn2+, Cr3+, and Mg2+ by fluorescence spectroscopy changes in H2O/DMSO (1:9, v/v) solution with specific selectivity and high sensitivity. The fluorescence color of the solution containing sensor L showed a remarkable change from blue to colorless only after the addition of Hg2+ in aqueous media while other cations did not cause obvious color changes. Moreover, further study demonstrates that the detection limit on the fluorescence response of the sensor to Hg2+ is down to 9.56 × 10-9 M, which is far lower than the maximum level for mercury of 0.01 M in drinking water, from EPA guidelines. Test strips based on L were fabricated, which could act as convenient and efficient Hg2+ test kits. Thus, the probe should have potential applications in an aqueous environment for the monitoring of mercury.
Synthesis, X-ray structure and theoretical investigation of 2-(2’-quinolyl)benzimidazole metal complexes
Sahki, Feriel Aouatef,Messaadia, Lyamine,Merazig, Hocine,Chibani, Aissa,Bouraiou, Abdelmalek,Bouacida, Sofiane
, p. 21 - 29 (2017)
Synthesis, characterization and DFT analysis of 2-(1H-benzo[d]imidazol-2-yl)quinoline (BQ) and its cobalt and manganese coordination compounds {Co(DMF)(BQ) Cl 2} and {Mn(DMF)(BQ) Cl 2} have been described. The ligand, 2-(1H-benzo[d]imidazol-2-yl)quinoline (BQ) crystallizes in non-centrosymmetric monoclinic crystal system with cell parameters a = 12.9280(4) ?, b = 7.9429(3) ?, c = 25.8478(9) ?, α = γ=90°,β=103.005(2)°. {Co(DMF)(BQ)Cl 2} and {Mn(DMF)(BQ)Cl 2} crystallized in triclinic space group P-1. The metal(II) environment exhibits trigonal bipyramidal coordination. These complexes show presence of N–H …Cl, C–H..Cl hydrogen bonds and strong intramolecular C–H..O interactions. The structure parameters were calculated and they are in good agreement with those observed experimentally. Theoretically calculated frontier molecular orbitals (HOMO–LUMO) of the complexes and their energies indicate intermolecular charge transfer and delocalization of electron density within the molecule. [Figure not available: see fulltext.]
POTENT AND SELECTIVE INHIBITORS OF CYTOCHROME P450
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Paragraph 0107, (2021/08/13)
Inhibitors of the enzyme cytochrome P450 (CYP), including 1B1 (CYP1B1), 1A1 (CYP1A1) and 19A1 (CYP19A1) are provided, and are useful in medical applications. Disclosed are highly potent and selective compounds that can be used in chemoprevention to ameliorate malignant changes induced by CYP, or to aid in treatment, including restoration of chemotherapeutic efficacy.
Oxidative NHC catalysis for base-free synthesis of benzoxazinones and benzoazoles by thermal activated NHCs precursor ionic liquid catalyst using air as oxidant
Guan, Jiali,Liu, Wei,Liu, Yuchen,Song, Zhibin,Tao, Duan-Jian,Yan, Jieying,Yuan, Jian-Jun,Zhou, Youkang
, (2020/05/25)
A reusable thermal activated NHC precursor ionic liquid catalyst ([BMIm]2[WO4]) has been prepared and developed for the synthesis of nitrogen-containing heterocycles such as benzoxazinones and benzoazoles through imines activation. [BMIm]2[WO4] exhibited the good activity for the base-free condensation and oxidative NHC catalysis tandem under air atmosphere. The catalyst can be recovered and reused for at least five runs in gram scale synthesis without any decrease in catalytic activity. Furthermore, the control experiments demonstrated that the reaction involved formation of aromatic aldimines, NHC-catalyzed oxidative formation of imidoyl azoliums and intramolecular cyclization to generate the product.