1404454-56-3

Basic information

• Product Name: 4-(4-butylphenyl)pyrrolo[1,2-a]quinoline
• Synonyms: 4-(4-butylphenyl)pyrrolo[1,2-a]quinoline
• CAS NO: 1404454-56-3
• Molecular Weight: 299.415
• Mol File: 1404454-56-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-butylphenyl)pyrrolo[1,2-a]quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-butylphenyl)pyrrolo[1,2-a]quinoline(1404454-56-3)
• EPA Substance Registry System: 4-(4-butylphenyl)pyrrolo[1,2-a]quinoline(1404454-56-3)

Safety Data

• Hazardous Substances Data: 1404454-56-3(Hazardous Substances Data)

Upstream product

• 583-55-1 1-Bromo-2-iodobenzene 
• 69907-27-3 1-(2-bromophenyl)-1H-pyrrole 
• 79887-09-5 (4-butylphenyl)acetylene 

Relevant articles and documents

Palladium-catalyzed sonogashira-coupling conjoined C-H activation: A regioselective tandem strategy to access indolo- and pyrrolo[1,2- a ]quinolines

An operationally simple approach for the regioselective tandem synthesis of indolo[1,2-a]quinolines 4a-v and pyrrolo[1,2-a]quinolines 5a-k from 1-(2-bromophenyl)-1H-indole/pyrrole/imidazole 1a-c, 2a,b by the palladium-catalyzed sequential C-C bond formation is described. The developed approach involves the palladium-catalyzed Sonogashira coupling followed by the intramolecular C-C bond formation via C-H activation, which leads to the formation of 6-endo-dig cyclized product. This synthetic methodology accommodates wide functional group variation on alkyne, which proves to be advantageous for the structural and biological activity assessments.