1404513-42-3

Basic information

• Product Name: 5'-O-(4,4'-dimethoxytriphenylmethyl)-5-(2-nitro-1H-imidazol-1-yl)methyl-2'-deoxythymidine
• Synonyms: 5'-O-(4,4'-dimethoxytriphenylmethyl)-5-(2-nitro-1H-imidazol-1-yl)methyl-2'-deoxythymidine
• CAS NO: 1404513-42-3
• Molecular Weight: 655.664
• Mol File: 1404513-42-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5'-O-(4,4'-dimethoxytriphenylmethyl)-5-(2-nitro-1H-imidazol-1-yl)methyl-2'-deoxythymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4'-dimethoxytriphenylmethyl)-5-(2-nitro-1H-imidazol-1-yl)methyl-2'-deoxythymidine(1404513-42-3)
• EPA Substance Registry System: 5'-O-(4,4'-dimethoxytriphenylmethyl)-5-(2-nitro-1H-imidazol-1-yl)methyl-2'-deoxythymidine(1404513-42-3)

Safety Data

• Hazardous Substances Data: 1404513-42-3(Hazardous Substances Data)

Upstream product

• 1404513-32-1 3',5'-bis-O-acetyl-(5-2-nitro-1H-imidazol-1-ylmethyl-2'-deoxythymidine) 
• 58589-18-7 3',5'-di-O-acetyl-5-bromomethyl-2'-deoxyuridine 
• 6979-97-1 3',5'-diacetylthymidine 
• 50-89-5 thymidine 

Downstream Products

• 1404513-45-6 5'-O-(4,4'-dimethoxytriphenylmethyl)-5-((2-nitro-1H-imidazol-1-yl)methyl)-2'-deoxyuridine-3'-(2-cyanoethyl)-N,N-diisopropylphosphoramidite 

Relevant articles and documents

Hypoxia-selective DNA interstrand cross-link formation by two modified nucleosides

The clean crossed code: Two nitroimidazole-modified thymidines 1 a and 1 b were synthesized and incorporated into DNA oligomers. The 350 nm photolysis of 1 a and 1 b generated a 5-(2'-deoxyuridinyl)methyl radical that induced DNA interstrand cross-links (ICL; see scheme). A higher ICL yield was observed under hypoxic conditions than under aerobic conditions. Copyright