140455-48-7Relevant articles and documents
A synthesis of 2-substituted 2-aminoethanol derivatives having inhibitory activity against protein kinase C
Iwasaki,Yamazaki,Nishitani,Kondo,Sato
, p. 122 - 126 (1992)
A series of 2-aminoethanol derivatives was synthesized and their inhibitory activities against protein kinase C were investigated. Among these compounds, 2-endo-hexadecylamino-5-norbornene-2-exo-methanol (4h) and 2-endohexadecylamino-5-norbornene-2,3-exo-dimethanol (4i) inhibited protein kinase C at the IC50 values of 2 x 10-5 and 1 x 10-5 M, respectively, but not protein kinase A at a concentration of 1 x 10-3 M. The structure-activity relationships are discussed.