140468-55-9 Usage
Chemical classification
Oxazole
Structure
Heterocyclic compound with a five-membered aromatic ring containing one oxygen and one nitrogen atom
Derivative
Dihydro derivative of 8H-indeno[1,2-d]oxazole
Substituent
Phenyl group attached at the 2-position
Applications
Used in organic synthesis and pharmaceutical research as a building block for new drugs and materials
Potential properties
May possess biological and pharmacological properties
Interest
Subject of further investigation in medicinal chemistry field
Check Digit Verification of cas no
The CAS Registry Mumber 140468-55-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,0,4,6 and 8 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 140468-55:
(8*1)+(7*4)+(6*0)+(5*4)+(4*6)+(3*8)+(2*5)+(1*5)=119
119 % 10 = 9
So 140468-55-9 is a valid CAS Registry Number.
140468-55-9Relevant articles and documents
Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1'phenyl substituents: X-ray crystal structure assisted design
Thompson,Fitzgerald,Holloway,Emini,Darke,McKeever,Schleif,Quintero,Zugay,Tucker,Schwering,Homnick,Nunberg,Springer,Huff
, p. 1685 - 1701 (2007/10/02)
By tethering of a polar hydrophilic group to the P1 or P1' substituent of a Phe-based hydroxyethylene isostere, the antiviral potency of a series of HIV protease inhibitors was improved. The optimum enhancement of anti-HIV activity was observed with the 4-morpholinylethoxy substituent. The substituent effect is consistent with a model derived from inhibitor docked in the crystal structure of the native enzyme. An X-ray crystal structure of the inhibited enzyme determined to 2.25 A verifies the modeling predictions.
