140472-35-1

Basic information

• Product Name: N-(o-nitrobenzoyl)-acetamide
• Synonyms: N-(o-nitrobenzoyl)-acetamide
• CAS NO: 140472-35-1
• Molecular Weight: 208.174
• Mol File: 140472-35-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(o-nitrobenzoyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(o-nitrobenzoyl)-acetamide(140472-35-1)
• EPA Substance Registry System: N-(o-nitrobenzoyl)-acetamide(140472-35-1)

Safety Data

• Hazardous Substances Data: 140472-35-1(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 612-24-8 o-nitrobenzonitrile 
• 610-15-1 2-nitrobenzamide 
• 75-36-5 acetyl chloride 

Downstream Products

• 1361032-70-3 3-methyl-5-(2-nitrophenyl)-1-phenyl-1H-1,2,4-triazole 
• 1769-24-0 4-hydroxy-2-methylquinazoline 
• 60-35-5 acetamide 
• 31499-90-8 2,1-benzisoxazol-3(1H)-one 
• 140472-38-4 4-hydroxy-2-methylquinazoline 1-oxyde 

Relevant articles and documents

Alumina-promoted synthesis of N-aryl-1,2,4-triazoles from substituted hydrazines and imides

Herein we report the highly efficient, environmentally friendly alumina-promoted synthesis of N-aryl-1,2,4-triazoles with a wide variety of substitution patterns from commercially available hydrazines with symmetrical and unsymmetrical imides. Aromatic hydrazines with a variety of substitution patterns provided the corresponding 1,2,4-triazoles in very high yields. Unsymmetrical imides with a wide variety of functional groups also provide the respective triazoles with high yield and complete regioselectivities. The high productivity and mild conditions allow for the large-scale preparation of 1,2,4-triazoles.

Electrochemical reduction of N-(o-nitrobenzoyl) and N-(o-nitrobenzyl)-amides or imides. Electrosynthesis of quinazoline derivatives.

Controlled potential electrolysis at a mercury pool cathode, carried out at the plateau of the first reduction wave of o-nitrobenzoylacetamide, leads to 4-hydroxy-2-methylquinazoline 1-oxide, resulting from a ring closure of the phenylhydroxylamine intermediate.In the same conditions, o-nitrobenzoylsuccinimide gives rise to a tricyclic compound which undergoes a nucleophilic attack from the electrolysis medium, with formation of 4-hydroxyquinazoline 1-oxide bearing at the position 2, either a propanoate group (acidic media) or a propanamido group (ammoniacal buffer).At last, the hydroxylamino derivative issued from o-nitrobenzoyl- phtalimide reduction, disproportionates in acidic medium and a mixture of 2-(o-carboxyphenyl)-4-hydroxyquinazoline 1-oxide and of the parent quinazoline is obtained at the term of the electrolysis.As a matter of comparison, the parent o-nitrobenzyl substrates have been studied; no ring closure occurs at the hydroxylamino stage but quinazoline derivatives can be obtained from the corresponding anilines by electroreduction at more negative potentials. Key words: polarography / cyclic voltammetry / controlled potential electrolysis / quinazoline 1-oxyde / quinazoline