140633-58-5 Usage
Description
8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-chlorophenyl)-8-methyl-, (1R,2S,3S,5S)is a complex organic compound with a unique molecular structure. It is characterized by its bicyclic ring system and the presence of a carboxylic acid group, a chlorine atom, and a methyl group. 8-Azabicyclo[3.2.1]octane-2-carboxylic acid,
3-(4-chlorophenyl)-8-methyl-, (1R,2S,3S,5S)has specific stereochemistry, with the (1R,2S,3S,5S) configuration indicating the arrangement of its atoms in three-dimensional space.
Uses
Used in Pharmaceutical Industry:
8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-chlorophenyl)-8-methyl-, (1R,2S,3S,5S)is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and functional groups make it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Research and Development:
8-Azabicyclo[3.2.1]octane-2-carboxylic acid,
3-(4-chlorophenyl)-8-methyl-, (1R,2S,3S,5S)is also used in research and development for studying its chemical properties, reactivity, and potential interactions with other molecules. Understanding its behavior can lead to the discovery of new reactions and applications in the field of organic chemistry.
Used in Drug Synthesis:
8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-chlorophenyl)-8-methyl-, (1R,2S,3S,5S)serves as a key intermediate in the synthesis of RTI-113 (R701110), a 3-phenyltropane analogue that acts as a potent and selective dopamine uptake inhibitor. RTI-113 has shown promise in reducing cocaine self-administration at high occupancy of the dopamine transporter, making it a potential candidate for the development of agonist therapies for cocaine dependence.
Used in Cocaine Addiction Treatment:
As a derivative of RTI 70, this compound plays a role in the development of potential treatments for cocaine addiction. RTI 70 is a cocaine derivative that prevents cocaine and MK-801 inhibition of the nicotinic acetylcholine receptor (nAChR). The compound's ability to modulate the effects of cocaine on the nAChR makes it a valuable tool in the development of therapies for cocaine dependence.
Check Digit Verification of cas no
The CAS Registry Mumber 140633-58-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,0,6,3 and 3 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 140633-58:
(8*1)+(7*4)+(6*0)+(5*6)+(4*3)+(3*3)+(2*5)+(1*8)=105
105 % 10 = 5
So 140633-58-5 is a valid CAS Registry Number.
140633-58-5Relevant articles and documents
Synthesis of a β-CCT-lanthanide conjugate for binding the dopamine transporter
Naumiec, Gregory R.,Lincourt, Grace,Clever, Jeremy P.,McGregor, Michael A.,Kovoor, Abraham,Deboef, Brenton
, p. 2537 - 2540 (2015/04/13)
The development of a β-CCT-lanthanide conjugate that binds the dopamine transporter (DAT) with high affinity (Kd = 303 nM) is described. Contrast agents such as the one described herein could be used as molecular probes to directly study the binding of small molecules to receptors such as DAT via MRI, PET or SPECT. This journal is
Synthesis and evaluation of novel N-fluoropyridyl derivatives of tropane as potential PET imaging agents for the dopamine transporter
Liu, Jingying,Zhu, Lin,Pl?ssl, Karl,Lieberman, Brian P.,Kung, Hank F.
scheme or table, p. 2962 - 2965 (2011/06/26)
A series of novel N-fluoropyridyl-containing tropane derivatives were synthesized and their binding affinities for the dopamine transporter (DAT), serotonin transporter (SERT) and norepinephrine (NET) were determined via competitive radioligand binding as
Synthesis and binding affinities of 2β-(3-iodoallyloxycarbonyl)-3β-(4-substituted-aryl)tropane analogues as ligands for the dopamine transporter studies
Chung, Kyoo-Hyun,Lim, Choong Hwan,Lee, Dong Reyoul,Jin, Changbae,Chi, Dae Yoon
, p. 3077 - 3080 (2007/10/03)
Tropane analogues from cocaine, which is known to be one of the most reinforcing and addictive compounds, were designed, synthesized, and characterized for inhibition of presynaptic uptake of dopamine (DA) in brain. Eight new derivatives of 3β-aryl-2β-(3-iodoallyloxycarbonyl)tropanes were synthesized and tested for their potential abilities to displace [3H]2β-carbomethoxy-3β-(4-fluorophenyl)tropane (WIN 35,428) binding to the rat striatal membranes.