14064-39-2Relevant articles and documents
Four new pregnane glycosides from Gymnema latifolium and their α-glucosidase and α-amylase inhibitory activities
Yen, Duong Thi Hai,Trang, Do Thi,Tai, Bui Huu,Doan, Vu Van,Yen, Pham Hai,Nhiem, Nguyen Xuan,Van Minh, Chau,Hoang Duc, Manh,Park, SeonJu,Hyuk Lee, Jae,Kim, Sun Yeou,Kim, Seung Hyun,Kiem, Phan Van
supporting information, p. 4460 - 4467 (2020/03/03)
Four new pregnane glycosides, gymlatifosides A - D (1 ? 4) and one known pregnane glycoside, verticilloside J (5) were isolated from the leaves of Gymnema latifolium Wall. ex Wight. Their chemical structures were elucidated on the basis of extensive spectroscopic methods, including 1D, 2D NMR, HR-ESI-MS, and in comparison with the reported data. All these compounds were tested for α-glucosidase and α-amylase inhibitory activities. Compound 5 exhibited the most anti α-glucosidase activity with inhibitory percentage of 37.8 ± 1.5% at the concentration of 200 μM. Compounds 1–4 showed moderate anti α-glucosidase activity with inhibitory percentage ranging from 7.0 to 30.1%. In addition, all compounds 1–5 showed moderate/weak anti α-amylase activity in the investigated test.
Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum
Jin, Qinghao,Han, Xiang Hua,Yun, Cheong-Yong,Lee, Chul,Lee, Jin Woo,Lee, Dongho,Lee, Mi Kyeong,Jung, Sang-Hun,Hong, Jin Tae,Kim, Youngsoo,Hwang, Bang Yeon
supporting information, p. 1252 - 1256 (2018/03/12)
Bioassay-guided fractionation of the methanolic extract from the roots of Cynanchum atratum has resulted in the isolation of three new pregnane glycosides (1–3) along with four known compounds (4–7). Their structures were identified by analysis of the spectroscopic data including extensive 2D NMR. All of the isolates were evaluated for their potential to inhibit the melanin production in α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells. Of these, compounds 4–7 dose-dependently inhibited the melanin production with the IC50 values ranging from 4 μM to 33 μM.
New C21 steroidal glycosides from the roots of Cynanchum stauntonii and their protective effects on hypoxia/reoxygenation induced cardiomyocyte injury
Lei, Qiao-Shi,Zuo, Yi-Han,Lai, Chang-Zhi,Luo, Jin-Fang,Pang, Shu-Wen,Zhou, Hua,Yao, Xin-Sheng,Tang, Jin-Shan
, p. 1716 - 1722 (2017/07/27)
Phytochemical investigations from the roots of Cynanchum stauntonii led to obtain four new C21 steroidal glycosides (1–4) and one known compound stauntoside F (5). Their chemical structures were characterized by sophisticated analyses of IR, HR