140658-46-4Relevant articles and documents
An efficient catalytic deprotection of thioacetals employing bismuth triflate: Synthesis of pyrrolo[2,1-c] [1,4] benzodiazepines
Kamal, Ahmed,Reddy,Reddy, D. Rajasekhar
, p. 2857 - 2860 (2003)
A simple and efficient deprotection of thioacetals has been achieved by employing bismuth triflate. This method has been effectively employed in the preparation of DNA-binding pyrrolo[2,1-c] [1,4]benzodiazepine and its dimers.
Synthesis of sequence-selective C8-linked pyrrolo[2,1-c][1,4]benzodiazepine DNA interstrand cross-linking agents
Thurston, David E.,Bose, D. Subhas,Thompson, Andrew S.,Howard, Philip W.,Leoni, Alberto,Croker, Stephen J.,Jenkins, Terrence C.,Neidle, Stephen,Hartley, John A.,Hurley, Laurence H.
, p. 8141 - 8147 (2007/10/03)
An efficient convergent synthesis of a homologous series of C8-linked pyrrolobenzodiazepine dimers with remarkable DNA interstrand cross-linking activity and potent in vitro cytotoxicity is reported. The 'amino thioacetal' cyclization procedure was used t
Effect of linker length on DNA-binding affinity, cross-linking efficiency and cytotoxicity of C8-linked pyrrolobenzodiazepine dimers
Bose,Thompson,Smellie,Berardini,Hartley,Jenkins,Neidle,Thurston
, p. 1518 - 1520 (2007/10/02)
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