140685-07-0

Basic information

• Product Name: L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl]-, methyl ester
• CAS NO: 140685-07-0
• Molecular Formula: C27H34N2O6
• Molecular Weight: 482.577
• Mol File: 140685-07-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl]-, methyl ester(140685-07-0)
• EPA Substance Registry System: L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl]-, methyl ester(140685-07-0)

Safety Data

• Hazardous Substances Data: 140685-07-0(Hazardous Substances Data)

Upstream product

• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 2133-40-6 L-proline methyl ester monohydrochloride 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 

Downstream Products

• 140685-27-4 Boc-Ser(Bzl)-Met-Tyr(Bzl)-Pro-Ser(Bzl)-Cys(Bzl)-NH₂ 
• 140685-11-6 Fmoc-Thr(Bzl)-Ser(Bzl)-Met-Tyr(Bzl)-Pro-OH 
• 140685-21-8 Boc-Thr-Ser-Met-Tyr(Bzl)-Pro-Ser-Cys(Bzl)-NH₂ 
• 140685-25-2 Boc-Met-Tyr(Bzl)-Pro-Ser(Bzl)-Cys(Bzl)-NH₂ 
• 140685-20-7 Boc-Thr-Ser-Met-Tyr(Bzl)-Pro-OH 
• 140702-24-5 Boc-Ser(Bzl)-Met-Tyr(Bzl)-Pro-OH 
• 140685-36-5 Boc-Ser-Met-Tyr(Bzl)-Pro-OH 
• 140702-23-4 Boc-Met-Tyr(Bzl)-Pro-OH 
• 217977-51-0 (S)-1-[(S)-3-(4-Benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propyl]-pyrrolidine-2-carboxylic acid 
• 284038-41-1 Tyrosine-Proline-aza-Glycine-amide 

Relevant articles and documents

Degradation of azaglycinamido residues in model tripeptides derived from goserelin

Three model tripeptides, N-acetyl-Tyr-Pro-azaGly-NH2 (NYPaG), Tyr-Pro- azaGly-NH2 (YPaG), and Tyr-Pro-Gly-NH2(YPG), were subjected to a systematic degradation study to get information about the degradation of the azaglycinamido residue The degradation products were characterized with LC- MS. Main degradation products of NYPaG possess partially or totally eliminated azaglycinamido residues, while YPaG and YPG are exhibit cyclo(Tyr- Pro) formation, a diketopiperazine. The influence of the pH on the degradation rate constant k(obs) was investigated for NYPaG and YPaG in the pH range 0.4-11. An U-shaped profile with an inflexion around pH 9 was found for NYPaG while the degradation rate of YPaG was independent of the pH. NYPaG apparently was subject to proton-, solvent-, and hydroxyl-catalyzed degradation reactions whereas YPaG only underwent solvent-catalyzed reactions. Some influence of acetate and phosphate ions on k(obs) was found for YPaG. Arrhenius plots of NYPaG and YPaG were found to be linear. (C) 2000 Wiley-Liss, Inc.

SYNTHESIS OF HBsAG SEGMENTS IN SOLUTION

Immunization with segments (117-137 and 121-137) of the surface antigen of hepatitis B virus (HBsAg) had been reported to protect against HB infection.Therefore in addition to these peptides, HBsAg(124-137) and the three C-terminally amidated derivatives