140685-82-1

Basic information

• Product Name: Ethanedioic acid, 4-[2-(ethoxycarbonyl)-4-(1-methylethyl)-5-oxazolyl]phenyl ethyl ester
• CAS NO: 140685-82-1
• Molecular Formula: C19H21NO7
• Molecular Weight: 375.378
• Mol File: 140685-82-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Ethanedioic acid, 4-[2-(ethoxycarbonyl)-4-(1-methylethyl)-5-oxazolyl]phenyl ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanedioic acid, 4-[2-(ethoxycarbonyl)-4-(1-methylethyl)-5-oxazolyl]phenyl ethyl ester(140685-82-1)
• EPA Substance Registry System: Ethanedioic acid, 4-[2-(ethoxycarbonyl)-4-(1-methylethyl)-5-oxazolyl]phenyl ethyl ester(140685-82-1)

Safety Data

• Hazardous Substances Data: 140685-82-1(Hazardous Substances Data)

Upstream product

• 140685-80-9 2-amino-1-(p-hydroxyphenyl)-3-methyl-1-butanone hydrochloride 
• 140685-67-2 2-[1-(4-Benzyloxy-benzoyl)-2-methyl-propyl]-isoindole-1,3-dione 
• 140685-79-6 1-(p-benzyloxyphenyl)-2-bromo-3-methyl-1-butanone 
• 140685-78-5 1-(4-(benzyloxy)phenyl)-3-methylbutan-1-one 
• 34887-83-7 1-(4-hydroxyphenyl)-3-methylbutan-1-one 
• 140685-81-0 2-ethoxalylamino-1-(p-ethoxalyloxyphenyl)-3-methyl-1-butanone 

Downstream Products

• 140685-83-2 ethyl 5-(p-hydroxyphenyl)-4-isopropyl-2-oxazolecarboxylate 
• 140685-57-0 5-(p-hydroxyphenyl)-4-isopropyl-2-oxazolecarbohydrazide 
• 140685-65-0 4-isopropyl-5-(p-methoxymethoxyphenyl)-2-oxazolecarbohydrazide 
• 140685-87-6 ethyl 4-isopropyl-5-(p-methoxymethoxyphenyl)-2-oxazolecarboxylate 
• 140685-77-4 benzyl 5-(p-hydroxyphenyl)-4-isopropyl-2-oxazolecarbamate 
• 140685-66-1 benzyl 4-isopropyl-5-(p-methoxymethoxyphenyl)-2-oxazolecarbamate 

Relevant articles and documents

Synthesis and aldose reductase inhibitory activities of benzyl-2-oxazolecarbamate analogues

Various analogues of benzyl 5-phenyl-2-oxazolecarbamate (1a) were synthesized, and the structure-activity relationship of these analogues as aldose reductase inhibitor was studied. The carbamate group was necessary for the inhibitory activity. The introduction of an alkyl group at the C-4 position of 1a enhanced the inhibitory activity, however, the N-carboxymethyl group on the carbamate moiety counteracted to a hydrophobic interaction between the alkyl group at the C-4 position and the enzyme molecule.