140712-79-4 Usage
Description
N6-Benzoyl-3'-O-(4,4'-Dimethoxytrityl)-2'-Deoxyadenosine is a synthetic nucleoside analog that is structurally related to the natural nucleotide adenosine. It is characterized by the presence of a benzoyl group at the N6 position, a 4,4'-dimethoxytrityl group at the 3'-O position, and a 2'-deoxyribose sugar. N6-BENZOYL-3'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYADENOSINE plays a significant role in the activation of ribonucleotide reductase, an enzyme that converts ribonucleosides to deoxyribonucleosides, which are essential for DNA synthesis.
Uses
Used in Pharmaceutical Industry:
N6-Benzoyl-3'-O-(4,4'-Dimethoxytrityl)-2'-Deoxyadenosine is used as a pharmaceutical intermediate for the development of novel therapeutic agents. Its role in activating ribonucleotide reductase makes it a promising candidate for the treatment of various diseases, particularly those involving DNA synthesis and repair mechanisms.
As a Research Tool:
In the field of molecular biology and biochemistry, N6-Benzoyl-3'-O-(4,4'-Dimethoxytrityl)-2'-Deoxyadenosine serves as a valuable research tool for studying the mechanisms of ribonucleotide reductase and its role in DNA synthesis. It can be used to investigate the effects of this enzyme on cellular processes and to develop new strategies for targeting ribonucleotide reductase in the treatment of diseases.
In Drug Development:
N6-Benzoyl-3'-O-(4,4'-Dimethoxytrityl)-2'-Deoxyadenosine can be utilized in the development of new drugs targeting ribonucleotide reductase, which may have potential applications in cancer therapy, as well as in the treatment of viral and bacterial infections that rely on this enzyme for their replication.
In Diagnostic Applications:
N6-BENZOYL-3'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYADENOSINE may also find use in the development of diagnostic tools and assays for detecting and monitoring the activity of ribonucleotide reductase in various biological samples, which could be valuable for understanding the role of this enzyme in disease progression and for evaluating the efficacy of therapeutic interventions.
Check Digit Verification of cas no
The CAS Registry Mumber 140712-79-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,0,7,1 and 2 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 140712-79:
(8*1)+(7*4)+(6*0)+(5*7)+(4*1)+(3*2)+(2*7)+(1*9)=104
104 % 10 = 4
So 140712-79-4 is a valid CAS Registry Number.
140712-79-4Relevant articles and documents
Nucleosidyl-O-methylphosphonates: A pool of monomers for modified oligonucleotides
Rejman, Dominik,Masojidkova, Milena,Rosenberg, Ivan
, p. 1683 - 1705 (2007/10/03)
An unique set of 5′-O- and 3′-O-phosphonomethyl derivatives of four natural 2′-deoxyribonucleosides, 1-(2-deoxy-β-D-threo- pentofuranosyl)thymine, 5′-O- and 2′-O-phosphonomethyl derivatives of 1-(3-deoxy-β-D-erythro-pentofuranosyl)thymine, and 1-(3-deoxy-β-D- threo-pentofuranosyl)thymine has been synthesized as a pool of monomers for the synthesis of modified oligonucleotides. The phosphonate moiety was protected with 4-methoxy-1-oxido-2-pyridylmethyl ester group, serving also as an intramolecular catalyst in the coupling step.
Synthesis of 3'-azido-3'-deoxythymidine-terminated oligonucleotide
Esipov, Dmitriy S.,Esipova, Olga V.,Korobko, Vyacheslav G.
, p. 1697 - 1704 (2007/10/03)
A method of completely chemical synthesis of 3'-azido-3'- deoxythymidine-terminated oligonucleotides via 5'-H-phosphonate of AZT is described.
