140897-41-2 Usage
General Description
L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-4-methyl-, phenylmethyl ester is a chemical compound that is commonly used as a protecting group in peptide synthesis. It is a derivative of the amino acid leucine, which plays a crucial role in protein synthesis and energy production. The phenylmethyl ester group serves as a protective group, preventing unwanted reactions from occurring during the synthesis of peptides. L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-4-methyl-, phenylmethyl
ester is important in the field of pharmaceuticals and biochemistry, as it allows for the creation of specific peptide sequences with high precision and purity. Its use in peptide synthesis allows for the development of new pharmaceutical drugs and research into various biological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 140897-41-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,0,8,9 and 7 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 140897-41:
(8*1)+(7*4)+(6*0)+(5*8)+(4*9)+(3*7)+(2*4)+(1*1)=142
142 % 10 = 2
So 140897-41-2 is a valid CAS Registry Number.
140897-41-2Relevant articles and documents
An efficient preparation of the pseudopeptide endothelin-B receptor selective antagonist BQ-788
He,Cody,Doherty
, p. 8262 - 8266 (1995)
The endothelins are a family of bicyclic 21 amino acid peptides that are potent and prolonged vasoconstrictors. BQ-788 is a modified tripeptide that is the only known highly potent and selective antagonist for the endothelin-B (ET(B)) receptor subtype discovered to date. Previous preparations of BQ-788 (N-(cis-2,6-dimethylpiperidinocarbonyl)-γ-methylleucyl-D-1-(methoxyca rbonyl)tryptophanyl-D-norleucine sodium salt) have suffered from several synthetic difficulties, including formation of the sterically hindered N-(cis-2,6-dimethylpiperidinocarbonyl)-γ-methylleucine, racemization of tryptophan during carbamination, and the facile reduction of the indole ring of tryptophan during catalytic hydrogenation. In order to prepare sufficient quantities of BQ-788 for in vitro and in vivo evaluations of the physiological significance of the ET(B) receptor, we have developed an efficient solution phase multiple-gram synthetic strategy.
