140934-40-3

Basic information

• Product Name: N-[3-Methoxy-4-(7-methyl-10H-indolo[3,2-b]quinolin-11-ylamino)-phenyl]-methanesulfonamide
• CAS NO: 140934-40-3
• Molecular Weight: 446.53
• Mol File: 140934-40-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-[3-Methoxy-4-(7-methyl-10H-indolo[3,2-b]quinolin-11-ylamino)-phenyl]-methanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-Methoxy-4-(7-methyl-10H-indolo[3,2-b]quinolin-11-ylamino)-phenyl]-methanesulfonamide(140934-40-3)
• EPA Substance Registry System: N-[3-Methoxy-4-(7-methyl-10H-indolo[3,2-b]quinolin-11-ylamino)-phenyl]-methanesulfonamide(140934-40-3)

Safety Data

• Hazardous Substances Data: 140934-40-3(Hazardous Substances Data)

Upstream product

• 106-49-0 p-toluidine 
• 14422-49-2 2-chloroacetamidobenzoic acid 
• 131058-39-4 2-[2-(p-tolylamino)acetamido]benzoic acid 
• 131058-40-7 7-methyl-5H-indolo[3,2-b]quinolin-11(10H)-one 
• 83209-83-0 4-methanesulfonamido-2-methoxyaniline hydrochloride 
• 131058-41-8 11-chloro-7-methyl-10H-indolo[3,2-b]quinoline 
• 57165-06-7 N-(4-amino-3-methoxyphenyl)methanesulfonamide 

Relevant articles and documents

Synthesis and antitumor activity of fused quinoline derivatives. V. Methylindolo[3,2-b]quinolines

Indolo[3,2-b]quinoline derivatives (1b-i) with a methyl group at each possible position have been synthesized. The 1-methyl (1b) and 9-methyl (1i) derivatives were inactive, but the 3-methyl (1d), 4-methyl (1e), and 6- methyl (1f) derivatives exhibited high treatment/control (T/C) value and cure rates against leukemia P388 in mice. These results indicated that modification of indolo[3,2-b]quinoline derivatives at 3, 4, and 6 positions may be useful approach for lead optimization.