14097-37-1

Basic information

• Product Name: 2-methyl-1,2,3,4-tetrahydroisoquinolin-6-amine
• Synonyms: 2-methyl-1,2,3,4-tetrahydroisoquinolin-6-amine;1,2,3,4-tetrahydro-2-methyl-6-isoquinolinamine;2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ylamine
• CAS NO: 14097-37-1
• Molecular Formula: C₁₀H₁₄N₂
• Molecular Weight: 162.23156
• Mol File: 14097-37-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 129-130 °C
• Boiling Point: 290.8±40.0 °C(Predicted)
• Appearance: /
• Density: 1.084±0.06 g/cm3(Predicted)
• PKA: 9.03±0.20(Predicted)
• CAS DataBase Reference: 2-methyl-1,2,3,4-tetrahydroisoquinolin-6-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-1,2,3,4-tetrahydroisoquinolin-6-amine(14097-37-1)
• EPA Substance Registry System: 2-methyl-1,2,3,4-tetrahydroisoquinolin-6-amine(14097-37-1)

Safety Data

• Hazardous Substances Data: 14097-37-1(Hazardous Substances Data)

Upstream product

• 14097-36-0 2-methyl-6-nitro-1,2,3,4-tetrahydro-isoquinoline 
• 1231163-94-2 2-methyl-6-trifluoroacetamido-1,2,3,4-tetrahydroisoquinoline 
• 164148-92-9 tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate 

Downstream Products

• 957469-32-8 benzyl (2R,4R)-4-methoxy-2-(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ylcarbamoyl)-pyrrolidine-1-carboxylate trifluoroacetate 
• 957469-28-2 benzyl (2S,4R)-4-methoxy-2-methyl-2-(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ylcarbamoyl)-pyrrolidine-1-carboxylate trifluoroacetate 
• 895638-08-1 2,2,2-trifluoro-N-[3-(3-{5-fluoro-2-[(2-methyl-1,2,3,4-tetrahydro-7-isoquinolinyl)amino]-4-pyrimidinyl}pyrazolo[1,5-a]pyridin-2-yl)phenyl]acetamide 
• 1080645-27-7 azetidine-1,2-dicarboxylic acid-1-[(4-chloro-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate 
• 1080645-31-3 2-methyl-azetidine-1,2-dicarboxylic acid-1-[(4-bromo-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate 

Relevant articles and documents

Identification of a series of 1,2,3,4-tethydroisoquinolinylbenzamides with potential anticonvulsant activity

A series of N-(tetrahydroisoquinolinyl)-2-methoxybenzamides was identified by high-throughput screening at the novel SB-204269 binding site. SAR studies have provided compounds 4 and 14 with high affinity and good anticonvulsant activity in animal models.

THERAPEUTIC COMPOUNDS

This invention relates to a novel class of substituted amino-ethoxy benzene derivatives of formula (I) which are inhibitors of serine proteases and to their use in treating aberrant serine protease activity in a mammal, contraception, anti-coagulant methods and methods for treating aberrant cell proliferation, tumours, cancer, angiogenesis, angiogenesis-based retinopathies, autoimmummune disease, inflammation, skin disease, arthritis, rheutmatoid arthritis, asthma, osteoarthritis and multiple sclerosis. (I), Wherein Rm, Rn, Rp, Rq, V, W, X, Y and R8 are as defined in the claims.