141047-46-3

Basic information

• Product Name: 4-HYDROXY-PIPERIDINE-1-CARBALDEHYDE
• Synonyms: 4-HYDROXY-PIPERIDINE-1-CARBALDEHYDE
• CAS NO: 141047-46-3
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.16
• Mol File: 141047-46-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-HYDROXY-PIPERIDINE-1-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-PIPERIDINE-1-CARBALDEHYDE(141047-46-3)
• EPA Substance Registry System: 4-HYDROXY-PIPERIDINE-1-CARBALDEHYDE(141047-46-3)

Safety Data

• Hazardous Substances Data: 141047-46-3(Hazardous Substances Data)

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 107-31-3 Methyl formate 
• 64-18-6 formic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 50978-45-5 3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide 
• 106-52-5 N-methyl-4-hydroxypiperidine 

Downstream Products

• 70978-88-0 4-(1,4-dioxapentyl)piperidine 
• 141048-05-7 4-Mercapto-piperidine-1-carbaldehyde 
• 141047-62-3 4-(2-propenoxy)piperidine amide of L-phenyllactic acid 
• 141047-65-6 4-(1-oxa-3-thiabutyl)piperidine amide of L-phenyllactic acid 
• 141047-66-7 4-(3-oxa-1-thiabutyl)piperidine amide of L-phenyllactic acid 
• 141047-82-7 2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-propionic acid 
• 141047-83-8 2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-butyric acid 
• 141047-85-0 2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-pentanoic acid 
• 141047-80-5 (S)-2-[(S)-2-(4-Allyloxy-piperidin-1-yl)-1-benzyl-2-oxo-ethoxy]-hexanoic acid 
• 141047-88-3 (S)-2-[(S)-1-Benzyl-2-(4-methylsulfanylmethoxy-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid 
• 141047-89-4 (S)-2-[(S)-1-Benzyl-2-(4-methoxymethylsulfanyl-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid 
• 141047-67-8 (S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethylamino]-hexanoic acid ethyl ester 
• 141047-58-7 [(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid benzyl ester 
• 130317-49-6 (S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-N-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-propionamide 

Relevant articles and documents

An organophotocatalytic late-stage N-CH3 oxidation of trialkylamines to N-formamides with O2 in continuous flow

We report an organophotocatalytic, N-CH3-selective oxidation of trialkylamines in continuous flow. Based on the 9,10-dicyanoanthracene (DCA) core, a new catalyst (DCAS) was designed with solubilizing groups for flow processing. This allowed O2 to be harnessed as a sustainable oxidant for late-stage photocatalytic N-CH3 oxidations of complex natural products and active pharmaceutical ingredients bearing functional groups not tolerated by previous methods. The organophotocatalytic gas-liquid flow process affords cleaner reactions than in batch mode, in short residence times of 13.5 min and productivities of up to 0.65 g per day. Spectroscopic and computational mechanistic studies showed that catalyst derivatization not only enhanced solubility of the new catalyst compared to poorly-soluble DCA, but profoundly diverted the photocatalytic mechanism from singlet electron transfer (SET) reductive quenching with amines toward energy transfer (EnT) with O2

N-Formylsaccharin: A new formylating agent

N-Formylsaccharin, a very cheap reagent, has been revealed to be an efficient and chemoselective formylating agent of amines. Georg Thieme Verlag Stuttgart New York.

Indium-catalyzed N -formylation of amines under solvent-free conditions

We have developed a simple, mild method for N-formylation of a wide variety of amines in the presence of indium metal as a catalyst under solvent-free conditions. This reaction is applicable to the chemoselective N-formylation of amino groups and -amino acid esters without epimerization. Georg Thieme Verlag Stuttgart.