141072-06-2

Basic information

• Product Name: methyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate
• Synonyms: methyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate
• CAS NO: 141072-06-2
• Molecular Weight: 247.254
• Mol File: 141072-06-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: methyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate(141072-06-2)
• EPA Substance Registry System: methyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate(141072-06-2)

Safety Data

• Hazardous Substances Data: 141072-06-2(Hazardous Substances Data)

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 105-13-5 4-Methoxybenzyl alcohol 
• 2746-25-0 p-Methoxybenzyl bromide 
• 1729-67-5 Methyl 2,3-dibromopropionate 
• 70978-37-9 1-(azidomethyl)-4-methoxybenzene 
• 922-67-8 propynoic acid methyl ester 
• 67-56-1 methanol 
• 66086-33-7 Di-tert-butyl acetylenedicarboxylate 

Downstream Products

• 716361-79-4 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylic acid 

Relevant articles and documents

Catalytic cyclization of 2,3-dibromopropionates with benzyl azides to afford 1-benzyl-1,2,3-triazole-4-carboxylate: The use of A nontoxic bismuth catalyst

We synthesized 1,2,3-triazoles via the cyclization of 2,3-dibromopropionates with benzyl azides. Bismuth chloride is an efficient catalyst, and the reaction is accelerated by weak bases such as sodium acetate. A variety of functional groups are compatible

Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis

Microtubule affinity-regulating kinase 4 (MARK4) is a potential drug target as the same is found to be over expressed in several types of cancers. In search of effective MARK4 inhibitors, we have synthesized and characterized Isatin-triazole hydrazones (9a-i) and evaluated their inhibitory potential. Of all the compounds, 9g showed better binding affinity and enzyme inhibition potential in sub micromolar range. Human serum albumin (HSA) binding assay suggested an easy transportation of 9g in blood stream due to its binding affinity. In vitro anticancer studies performed on MCF-7, MDA-MB-435s and HepG2 cells using 9g showed inhibition of cell proliferation and cell migration. Further, 9g induces apoptosis in these cancerous cells, with IC50 values of 6.22, 9.94 and 8.14 μM, respectively. Putatively, 9g seems to cause oxidative stress resulting in apoptosis. Functional assay of 9g with a panel of 26 kinases showed MARK4 specific profile. In conclusion, 9g seems to possess an effective inhibitory potential towards MARK4 adding an additional repertoire to anticancer therapeutics.

EFFECT OF SOLVENT AND REACTION TIME ON THE PRODUCTS OF THE 1,3-DIPOLAR CYCLOADDITION OF SUBSTITUTED BENZYL AZIDES WITH DI-tert-BUTYL ACETYLENEDICARBOXYLATE

The 1,3-dipolar cycloaddition of substituted benzyl azides with di-tert-butyl acetylenedicarboxylate was found to be sensitive to the solvent (and time) of the reaction.Di-tert-butyl 1,2,3-triazole-4,5-dicarboxylate derivatives were obtained when the reac