1410747-77-1Relevant articles and documents
Lewis-acid-mediated ring-exchange reaction of dihydrobenzofurans and its application to the formal total synthesis of (-)-quinocarcinamide
Chiba, Hiroaki,Sakai, Yuki,Oishi, Shinya,Fujii, Nobutaka,Ohno, Hiroaki
, p. 6273 - 6276,4 (2012/12/12)
An unusual Lewis-acid-mediated ring-exchange reaction of dihydrobenzofurans is described. The fused tricyclic ring system is the key structural element for this reaction as it restricts C-N bond rotation and/or destabilizes the benzofuran ring. We achieved the formal total synthesis of (-)-quinocarcinamide using a combination of this reaction and the Au(I)-catalyzed 6-endo-dig hydroamination of an alkyne.