141117-41-1Relevant articles and documents
Syntesis and Amnesia-Reversal Activity of a Series of 7- and 5-Membered 3-Acylamino Lactams
Angelucci, Luciano,Calvisi, Pina,Catini, Roberto,Cosentino, Ugo,Cozzolino, Roberto,et al.
, p. 1511 - 1519 (2007/10/02)
A series of 3-(acylamino)-ε-caprolactams and 3-(acylamino)-2-pyrrolidinones was synthesized.Some of these compounds reversed at different degrees electroconvulsive shock- and Scopolamine-induced amnesia, using a step-through passive avoidance in mice.Classical nootropic drugs, i.e., Aniracetam, Oxiracetam, and Piracetam, were used as reference compounds.Within the analyses of data performed, we introduced a new parameter, the confrontation index (CI), which is a function of Mann-Whitney's U statistic.The CI permits a common scale of activity of substances to be generated, independently of probabilistic hypotheses, with higher scores representing higher activities.The most active compounds were characterized by the formylamino and amino groups in the 3-position of the ring.None of the substances assayed showed any effect on spontaneous behavior and neurovegetative system.
